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Cow (Bovine) Monoclonal ARF1 Primary Antibody for ICC, FACS - ABIN152664
Lu, Horstmann, Ng, Hong: Regulation of Golgi structure and function by ARF-like protein 1 (Arl1). in Journal of cell science 2002
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Arabidopsis thaliana Polyclonal ARF1 Primary Antibody for IF, WB - ABIN2688655
Pimpl, Movafeghi, Coughlan, Denecke, Hillmer, Robinson: In situ localization and in vitro induction of plant COPI-coated vesicles. in The Plant cell 2001
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This study suggests that simultaneous blockade of Arf1 and Ras activation in prostate cancer cells is a potential targeted therapeutic strategy for preventing prostate cancer development.
Silencing of ARF1 impaired RAC1 recruitment to leading edge in neutrophil chemotaxis.
Data show that only ADP-ribosylation factor 1 (ARF1) promoter hypermethylation was significantly associated with epidermal growth factor receptor (显示 EGFR 抗体) gene (EGFR (显示 EGFR 抗体)) gene amplification in glioblastoma.
The zebrafish-metastasis model confirms that the ARF1 gene depletion suppresses breast cancer cells to metastatic disseminate throughout fish body.
ARF1 is a critical regulator in prostate cancer progression
our findings demonstrate that ARF1 is a molecular switch for cancer progression and thus suggest that limiting the expression/activation of this GTPase (显示 RACGAP1 抗体) could help improve outcome for breast cancer patients.
changes in distinct lipid ratios may converge on ARF1 to increase SBP-1 (显示 MEGF8 抗体)/SREBP-1 (显示 SREBF1 抗体) activity.
Experiments using a mutant form of ARF1 affecting GTP (显示 AK3 抗体) hydrolysis suggest that ARF1[GTP (显示 AK3 抗体)] is functionally required for the tubules to form.
ARNO-ARF1 regulates formation of podosomes by inhibition of RhoA/myosin-II and promotion of actin core assembly.
Activation of ARF1 dissociates ADRP (显示 PLIN2 抗体) from lipid droplets. A constitute active form of ARF1 (ARF1Q71I) promotes HCV assembly. ADRP (显示 PLIN2 抗体) played a positive role in Hepatitis C virus replication and negative role in Hepatitis C virus assembly.
The authors found that Arf1 occupies contrasting molecular environments within the Coat Protein (显示 GOLPH3 抗体) Complex I, leading them to hypothesize that some Arf1 molecules may regulate vesicle assembly while others regulate coat disassembly.
ARF1 may be a plausible inter-player that mediates the transition to osteoclast fusion at multiple steps during osteoclast differentiation.
Increased gene dosage of Ink4a, Arf1 and p53 (显示 TP53 抗体) delays age-associated central nervous system functional decline.
ARF1/TBCE (显示 TBCE 抗体)-mediated cross-talk that coordinates COPI formation and tubulin (显示 TUBB 抗体) polymerization at the Golgi.
These data establish for the first time that the Arf1 gene is indispensable for mouse embryonic development after implantation.
Arf modulates LRP6 (显示 LRP6 抗体) phosphorylation for the transduction of Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling.
Down-regulation of ADP-ribosylation factor results in corneal neovascularization regression.
ARF1-dependent trafficking of procathepsin B and the maturation of autophagosomes results in cathepsin B-mediated trypsinogen activation induced by caerulein.
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling
findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (显示 NCS1 抗体) in mitochondrial function via its association with several mitochondrial proteins.
Vascular endothelial growth factor receptor-2 (显示 KDR 抗体) activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase (显示 NOS3 抗体) activation and nitric oxide release from endothelial cells
Data show that AP-1 (显示 JUN 抗体) recruitment to the cell membrane was found to be dependent on myristoylated ADP-ribosylation factor (ARF1), GTP (显示 AK3 抗体) or nonhydrolyzable GTP (显示 AK3 抗体)-analogs, tyrosine signals, and small amounts of phosphoinositides.
NCS-1 (显示 NCS1 抗体)-ARF1 interaction provides evidence for functional cross-talk between Ca(2 (显示 CA2 抗体)+)-dependent and ARF-dependent pathways in TGN (显示 TG 抗体) to plasma membrane traffic
The ARF1 machinery also might produce movement- and fission-promoting forces through actin polymerization.
Binding of cargo signal peptides to AP-1 (显示 JUN 抗体) induces a conformational change in its core domain that greatly enhances its interaction with Arf-1-GTP (显示 AK3 抗体).
Study shows that ARF DNA-binding domains ahomodimerize to generate cooperative DNA binding, which is critical for in vivo ARF5 (显示 ARF5 抗体)/MP function. Strikingly, DNA-contacting residues are conserved between ARFs, and found that monomers have the same intrinsic specificity; ARF1 and ARF5 (显示 ARF5 抗体) homodimers, however, differ in spacing tolerated between binding sites.
Data indicate that ArfGAP domain8 (AGD8) and ARF-GAP domain 9 (AGD9), are involved in the recruitment of Arf1-GDP to the Golgi apparatus .
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
ADP-ribosylation factor 1
, adp-ribosylation factor 1