Component of PA700, an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. Specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR). Could be E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Keppler, Archer: "Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex." in: The Journal of biological chemistry, Vol. 285, Issue 46, pp. 35665-74, (2010) (PubMed).