The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008].
Katkoori, Shanmugam, Jia, Vitta, Sthanam, Callens, Messiaen, Chen, Zhang, Bumpers, Samuel, Manne: "Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable stage III colorectal adenocarcinomas." in: PLoS ONE, Vol. 7, Issue 1, pp. e30020, (2012) (PubMed).
Yuan, Peng, Radhakrishnan, Seto: "Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein." in: The Journal of biological chemistry, Vol. 285, Issue 50, pp. 39329-38, (2011) (PubMed).
Yuan, Villagra, Peng, Coppola, Glozak, Sotomayor, Chen, Lane, Seto: "The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions." in: Molecular and cellular biology, Vol. 30, Issue 12, pp. 3004-15, (2010) (PubMed).
Wang, Heidt, Lee, Yang, Logsdon, Zhang, Fearon, Ljungman, Simeone: "Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization." in: Cancer cell, Vol. 15, Issue 3, pp. 207-19, (2009) (PubMed).
Kosaka, Inoue, Ohmachi, Yokoe, Matsumoto, Mimori, Tanaka, Watanabe, Mori: "Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer." in: Annals of surgical oncology, Vol. 14, Issue 9, pp. 2543-9, (2007) (PubMed).