TNKS 抗体
(Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS))
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
Popular TNKS 抗体
Latest Publications for our TNKS 抗体
: "Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics." in: Cancer cell, Vol. 7, Issue 1, pp. 25-37, (2005) (PubMed).: "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)." in: The Biochemical journal, Vol. 361, Issue Pt 3, pp. 451-9, (2002) (PubMed).
: "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14." in: The Journal of biological chemistry, Vol. 276, Issue 20, pp. 17172-80, (2001) (PubMed).
: "Tankyrase promotes telomere elongation in human cells." in: Current biology : CB, Vol. 10, Issue 20, pp. 1299-302, (2001) (PubMed).
Aliases for TNKS 抗体
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b (tnksb) 抗体tankyrase (TNKS) 抗体
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (Tnks) 抗体
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 S homeolog (tnks2.S) 抗体
tankyrase (Tnks) 抗体
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ARTD5 抗体
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D130072O21Rik 抗体
mTNKS1 抗体
PARP-5a 抗体
PARP5A 抗体
PARPL 抗体
pART5 抗体
TANK1 抗体
tankyrase-1 抗体
TIN1 抗体
TINF1 抗体
TNKS1 抗体
wu:fe02c12 抗体
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