(Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. [provided by RefSeq, Jul 2008].
Lei, Zhu, Zeng, Wang, Zhang, Chen, Mu, Huang: "SOX40L: an important inflammatory mediator in adult bronchial asthma." in: Annals of the Academy of Medicine, Singapore, Vol. 41, Issue 5, pp. 200-4, (2012) (PubMed).