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TNF Receptor Superfamily, Member 6 蛋白

(TNF Receptor Superfamily, Member 6 (FAS))
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011].

45 results

FAS 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
产品编号 ABIN7274589
 
FAS 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
产品编号 ABIN7274590
 
FAS 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
产品编号 ABIN7274587
 
FAS 宿主: 人 宿主: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
产品编号 ABIN1353663
 
FAS 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
产品编号 ABIN7320747
 
FAS 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
产品编号 ABIN7125404
 
FAS 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
产品编号 ABIN1353664
 
FAS 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95% by SDS-PAGE SDS, AcA Active
产品编号 ABIN7540045
 
FAS 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
产品编号 ABIN7320430
 
FAS 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
产品编号 ABIN7321232
 
FAS 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
产品编号 ABIN2181070
 
FAS 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % by SDS-PAGE. Active
产品编号 ABIN7534048
 
FAS 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant SDS, WB, ELISA
产品编号 ABIN7576022
 
FAS 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant SDS, WB, ELISA
产品编号 ABIN7580542
 
FAS 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 98 % pure Active
产品编号 ABIN935361
 
FAS 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % SDS, WB, Imm, PC
产品编号 ABIN7387028
 
FAS 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % SDS, WB, Imm, PC
产品编号 ABIN7401653
 
FAS 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % SDS, WB, Imm, PC
产品编号 ABIN7387025
 
FAS 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % SDS, WB, Imm, PC
产品编号 ABIN7402436
 
FAS 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % SDS, WB, Imm, PC
产品编号 ABIN7404125
 
  • 类型 Protein
    • Protein
  • 应用范围
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • ELISA
    • Immunogen (Imm)
    • Positive Control (PC)
    • Antibody Production (AbP)
    • Standard (STD)
    • Activity Assay (AcA)
    • Affinity Purification (AP)
    • Protein Interaction (PI)
    • Antibody Array (AA)
    • Cell Culture (CC)
    • Functional Studies (Func)
    • Mass Spectrometry (MS)
  • 适用
    • Human
    • Mouse
    • Rat
    • Cow
    • Pig
    • Rhesus Monkey
    • Cynomolgus
    • Macaca nemestrina
    • Monkey
    • White-eyelid mangabey (Cercocebus)
  • 图像
  • Preservative free only
  • Carrier free only
  • 抗体来源
    • Escherichia coli (E. coli)
    • HEK-293 Cells
    • Yeast
    • Human Cells
    • Wheat germ
    • Baculovirus infected Insect Cells
    • HEK-293T Cells
    • Mammalian Cells
  • 抗原表位
    • AA 26-173
    • AA 21-170
    • AA 22-169
    • AA 22-172
    • AA 26-171
    • Transcript Variant 1
    • AA 37-274
    • AA 1-335
    • AA 17-173
    • AA 17-175
    • AA 188-319
    • AA 2155-2495
    • AA 23-170
    • AA 25-169
    • AA 26-170
    • AA 48-281
    • Soluble
    • partial
  • 标记
    • His tag
    • 非结合性
    • Fc Tag
    • His tag,GST tag
    • His tag,MBP tag
    • Fc Tag,His tag
    • GST tag
    • His-DYKDDDDK-Strep II Tag
    • His-SUMO Tag
    • MBP tag,His tag
    • Myc-DYKDDDDK Tag
  • 蛋白类型
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • 生物活性
    • Biologically Active
  • Supplier
    • antibodies-online
    • CUSABIO
    • OriGene
    • ACROBiosystems
    • Abbexa
    • Cloud-Clone
    • Cohesion Biosciences
    • ProSci
    • Signalway

Latest Publications for our TNF Receptor Superfamily, Member 6 蛋白

Orlinick, Vaishnaw, Elkon, Chao: "Requirement of cysteine-rich repeats of the Fas receptor for binding by the Fas ligand." in: The Journal of biological chemistry, Vol. 272, Issue 46, pp. 28889-94, (1997) (PubMed).

Liles, Kiener, Ledbetter, Aruffo, Klebanoff: "Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils." in: The Journal of experimental medicine, Vol. 184, Issue 2, pp. 429-40, (1996) (PubMed).

Tanaka, Suda, Takahashi, Nagata: "Expression of the functional soluble form of human fas ligand in activated lymphocytes." in: The EMBO journal, Vol. 14, Issue 6, pp. 1129-35, (1995) (PubMed).

Brunner, Mogil, LaFace, Yoo, Mahboubi, Echeverri, Martin, Force, Lynch, Ware: "Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas." in: Nature, Vol. 373, Issue 6513, pp. 441-4, (1995) (PubMed).

Yang, Merćep, Ware, Ashwell: "Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids." in: The Journal of experimental medicine, Vol. 181, Issue 5, pp. 1673-82, (1995) (PubMed).

Cheng, Zhou, Liu, Shapiro, Brauer, Kiefer, Barr, Mountz: "Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule." in: Science (New York, N.Y.), Vol. 263, Issue 5154, pp. 1759-62, (1994) (PubMed).

Takahashi, Tanaka, Brannan, Jenkins, Copeland, Suda, Nagata: "Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand." in: Cell, Vol. 76, Issue 6, pp. 969-76, (1994) (PubMed).

Aliases for TNF Receptor Superfamily, Member 6 蛋白

Fas cell surface death receptor (FAS) 蛋白
Fas (TNF receptor superfamily member 6) (Fas) 蛋白
Fas cell surface death receptor (Fas) 蛋白
Fas cell surface death receptor (fas) 蛋白
AI196731 蛋白
ALPS1A 蛋白
APO-1 蛋白
APO1 蛋白
APT1 蛋白
CD95 蛋白
FAS1 蛋白
FASTM 蛋白
lpr 蛋白
TNFR6 蛋白
TNFRSF6 蛋白
Tnfrsf6 蛋白
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