This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008].
Solga, Behrens, Ziemann, Riou, Berwanger, Becker, Garrett, de Angelis, Fischer, Coras, Barkovits, Marcus, Mahabir, Eichinger, Schröder, Noegel, Clemen: "CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells." in: European journal of cell biology, Vol. 98, Issue 5-8, pp. 151046, (2019) (PubMed).
Silva, Nascimento, Pereira, Siqueira, Brum, Jaeger, Miyabara: "β2-Adrenoceptor is involved in connective tissue remodeling in regenerating muscles by decreasing the activity of MMP-9." in: Cell and tissue research, Vol. 365, Issue 1, pp. 173-86, (2016) (PubMed).
Donover, Wojciechowski, Thirumaran, Zemba-Palko, Prendergast, Wallon: "Development of a monoclonal antibody that specifically detects tissue inhibitor of metalloproteinase-4 (TIMP-4) in formalin-fixed, paraffin-embedded human tissues." in: Journal of cellular biochemistry, Vol. 110, Issue 5, pp. 1255-61, (2010) (PubMed).
Tummalapalli, Heath, Tyagi: "Tissue inhibitor of metalloproteinase-4 instigates apoptosis in transformed cardiac fibroblasts." in: Journal of cellular biochemistry, Vol. 80, Issue 4, pp. 512-21, (2001) (PubMed).
Aliases for TIMP4 抗体
TIMP metallopeptidase inhibitor 4 (TIMP4) 抗体 TIMP metallopeptidase inhibitor 4, tandem duplicate 3 (timp4.3) 抗体 tissue inhibitor of metalloproteinase 4 (Timp4) 抗体 TIMP metallopeptidase inhibitor 4 (Timp4) 抗体 TIMP-4 抗体 TIMP4 抗体 timp4 抗体