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TIGAR 产品

(TP53 induced glycolysis regulatory phosphatase (TIGAR))

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This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008].

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Featured TIGAR Categories

TIGAR 抗体

High quality antibodies with extensive validation data.

TIGAR 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TIGAR 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7153207
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (2)
Cat. No. ABIN671286
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN1497017
Quantity 100 μL
Datasheet Datasheet

Recommended TIGAR ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6971306
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6206069
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN2870279
Quantity 96 tests
Datasheet Datasheet

Recommended TIGAR 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125420
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1347100
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7424359
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our TIGAR Products

Wong, Wong, Chan, Lam, Ho, Lau, Au, Chan, Tsang, Tsao, Lui, Chan: "TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells." in: Oncology letters, Vol. 9, Issue 2, pp. 569-574, (2015) (PubMed).

Lui, Wong, Ho, Ng, Lau, Tsui, Tsang, Tsao, Cheng, Ng, Ng, Lam, Hong, Lo, Mok, Chan, Mills: "Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death." in: Oncogene, Vol. 30, Issue 9, pp. 1127-34, (2011) (PubMed).

Corcoran, Huang, Sheikh: "The regulation of energy generating metabolic pathways by p53." in: Cancer biology & therapy, Vol. 5, Issue 12, pp. 1610-3, (2007) (PubMed).

Bensaad, Tsuruta, Selak, Vidal, Nakano, Bartrons, Gottlieb, Vousden: "TIGAR, a p53-inducible regulator of glycolysis and apoptosis." in: Cell, Vol. 126, Issue 1, pp. 107-20, (2006) (PubMed).

Bennett, Hodge, MacDougald, Schwartz: "Role of Wnt10b and C/EBPalpha in spontaneous adipogenesis of 243 cells." in: Biochemical and biophysical research communications, Vol. 302, Issue 1, pp. 12-6, (2003) (PubMed).

Guimaraes, Hainaut: "TP53: a key gene in human cancer." in: Biochimie, Vol. 84, Issue 1, pp. 83-93, (2002) (PubMed).

Synonyms and alternative names related to TIGAR

Trp53 induced glycolysis repulatory phosphatase (Tigar), AA793651, AI595337, C79710, C85509, Tigar

Protein level used designations for TIGAR

  • TP53-induced glycolysis and apoptosis regulator
  • fructose-2,6-bisphosphatase TIGAR
  • probable fructose-2,6-bisphosphatase TIGAR
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