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TFEB 产品

(Transcription Factor EB (TFEB))

Categories

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

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Featured TFEB Categories

TFEB 抗体

High quality antibodies with extensive validation data.

TFEB 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TFEB 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (1)
  • (5)
Cat. No. ABIN563503
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (8)
Cat. No. ABIN184741
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Dog, Goat, Horse, Human, Rabbit
Application WB
Validations
  • (5)
Cat. No. ABIN2787554
Quantity 100 μL
Datasheet Datasheet

Recommended TFEB ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Semi-Quantitative DNA-Binding ELISA
Validations
  • (2)
  • (2)
Cat. No. ABIN5526704
Quantity 96 tests
Datasheet Datasheet

Recommended TFEB 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125448
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1786750
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
  • (1)
Cat. No. ABIN2733467
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our TFEB Products

Mlejnek, Havlasek, Pastvova, Dolezel, Dostalova: "Lysosomal sequestration of weak base drugs, lysosomal biogenesis, and cell cycle alteration." in: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Vol. 153, pp. 113328, (2022) (PubMed).

Ye, Wang, Hu, Shen, Fan, Chen, Ma, Wu, Xiang: "Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR." in: Autophagy, Vol. 15, Issue 6, pp. 998-1016, (2019) (PubMed).

Kim, Kim, Kim, Kim, Han, Byeon, Lee, Kim: "HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer." in: Autophagy, Vol. 14, Issue 3, pp. 385-403, (2019) (PubMed).

Bhatelia, Singh, Prajapati, Sripada, Roy, Singh: "MITA modulated autophagy flux promotes cell death in breast cancer cells." in: Cellular signalling, Vol. 35, pp. 73-83, (2018) (PubMed).

Awad, Panicker, Deranieh, Srikanth, Brown, Voit, Peesay, Park, Zambidis, Feldman: "Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation." in: Stem cell reports, Vol. 9, Issue 6, pp. 1853-1867, (2017) (PubMed).

Luo, Ma, Yang, Wang, Zhang, Zhang, Liu, Liu: "TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1." in: The international journal of biochemistry & cell biology, Vol. 78, pp. 31-42, (2017) (PubMed).

Nakamura, Karalay, Jäger, Horikawa, Klein, Nakamura, Latza, Templer, Dieterich, Antebi: "Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals." in: Nature communications, Vol. 7, pp. 10944, (2016) (PubMed).

Song, Sun, Peluso, Zeng, Yu, Lu, Xu, Wang, Liu, Huang, Chen, Durairajan, Zhang, Zhou, Zhang, Lu, Ballabio, Medina, Guo, Li: "A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition." in: Autophagy, Vol. 12, Issue 8, pp. 1372-89, (2016) (PubMed).

Ju, Yan, Liu, Li, Sheng, Zhang, Li, Liang, Huang, Liu, Zhao, Zhang, Zou, Du, Zhong, Zhou, Yang, Lu, Tian, Li, Zhang, Jin, Jiang: "Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture." in: Journal of virology, Vol. 89, Issue 20, pp. 10347-58, (2015) (PubMed).

Kawano, Ito, Kanai, Nakamura, Tada, Takai, Horie, Kobayashi, Hino: "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." in: Oncology reports, Vol. 34, Issue 5, pp. 2251-8, (2015) (PubMed).

Synonyms and alternative names related to TFEB

transcription factor EB (TFEB), transcription factor EB (tfeb), transcription factor EB (Tfeb), alphatfeb, ALPHATFEB, BHLHE35, bHLHe35, MGC145796, tcfeb, TCFEB, Tcfeb, TFEB

Protein level used designations for TFEB

  • transcription factor EB
  • transcription factor EB-like
  • T-cell transcription factor EB
  • class E basic helix-loop-helix protein 35
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