(Transcription Factor AP-4 (Activating Enhancer Binding Protein 4) (TFAP4))
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]\; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009].
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Huang, Kesselman, Kizub, Guerrero-Preston, Ratovitski: "Phospho-?Np63?/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure." in: Cell cycle (Georgetown, Tex.), Vol. 12, Issue 4, pp. 684-97, (2013) (PubMed).
Tsujimoto, Ono, Sato, Nishida, Oguma, Tadakuma: "Regulation of the expression of caspase-9 by the transcription factor activator protein-4 in glucocorticoid-induced apoptosis." in: The Journal of biological chemistry, Vol. 280, Issue 30, pp. 27638-44, (2005) (PubMed).