The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].
Salas, Callaerts-Vegh, Arranz, Guix, DHooge, Esteban, De Strooper, Dotti: "Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity." in: PLoS ONE, Vol. 12, Issue 2, pp. e0171968, (2017) (PubMed).
Guix, Sannerud, Berditchevski, Arranz, Horré, Snellinx, Thathiah, Saido, Saito, Rajesh, Overduin, Kumar-Singh, Radaelli, Corthout, Colombelli, Tosi, Munck, Salas, Annaert, De Strooper: "Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments." in: Molecular neurodegeneration, Vol. 12, Issue 1, pp. 25, (2017) (PubMed).