This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008].
Popular TdT 蛋白
Aliases for TdT 蛋白
DNA nucleotidylexotransferase (DNTT) 蛋白 deoxynucleotidyltransferase, terminal (dntt) 蛋白 deoxynucleotidyltransferase, terminal (Dntt) 蛋白 DNA nucleotidylexotransferase L homeolog (dntt.L) 蛋白 DNA nucleotidylexotransferase (Dntt) 蛋白 terminal deoxynucleotidyl transferase (tdt) 蛋白 BB160593 蛋白 dntt 蛋白 dntt-A 蛋白 TdT 蛋白 TDT 蛋白 Tdt 蛋白