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抗Rat (Rattus) MAP4K1 抗体:
抗Human MAP4K1 抗体:
抗Mouse (Murine) MAP4K1 抗体:
Human Polyclonal MAP4K1 Primary Antibody for ELISA, WB - ABIN249544
Hu, Qiu, Wang, Meyer, Tan: Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. in Genes & development 1996
CUL7 (显示 CUL7 抗体)/Fbxw8 (显示 FBXW8 抗体) ubiquitin ligase-mediated HPK1 degradation revealed a direct link and novel role of CUL7 (显示 CUL7 抗体)/Fbxw8 (显示 FBXW8 抗体) ubiquitin ligase in the MAPK (显示 MAPK1 抗体) pathway, which plays a critical role in cell proliferation and differentiation.
HPK1 is critically involved in LFA-1 (显示 ITGAL 抗体)-mediated polymorphonuclear neutrophils trafficking during acute inflammation.
results indicate that uncleaved HPK1 is a positive regulator of vitamin D-induced differentiation in acute myeloid leukemia (显示 BCL11A 抗体) cells, but the cleaved HPK1 fragment inhibits differentiation
Pdcd4 (显示 PDCD4 抗体) knockdown up-regulates MAP kinase (显示 MAPK1 抗体) kinase kinase kinase 1 (MAP4K1) expression and increases phosphorylation of c-Jun (显示 JUN 抗体).
QVD and 1,25D-induced differentiation was accompanied by increased signaling by Hematopoietic Progenitor Kinase 1(HPK1), and the expression of transcription factors known to be involved in monocytic differentiation was increased.
HPK1 negatively regulates T cell activation by reducing the persistence of signaling microclusters.
The purpose of the study was to investigate the potential contribution of HPK1, MEKK1 (显示 MAP3K1 抗体), TAK1 (显示 MAP3K7 抗体), p-MKK4 (显示 MAP2K4 抗体) to the development of extramammary Paget disease
The catalytic activity of a hematopoietic cell-restricted, Ste20-related S/TPK, HPK1, is positively regulated by exposure to physiological concentrations of PGE2. HPK1 is a negative regulator of PGE2-induced FOS gene transcription.
PP4 (显示 ANXA5 抗体) is a positive regulator for HPK1 and the HPK1-JNK (显示 MAPK8 抗体) signaling pathway
Full activation of HPK1 is dependent on autophosphorylation of threonine 165 and phosphorylation of serine 171, which is a target site for protein kinase D (PKD) in vitro.
Introduction of three 4-R-hydroxyproline residues stabilizes the SH3m-cortactin (显示 CTTN 抗体) binding of HPK1 peptide.
a novel negative feedback regulation of BCR (显示 BCR 抗体) signaling by HPK1-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK (显示 BLNK 抗体)
HPK1 associates with SKAP1 (显示 SKAP1 抗体) to negatively regulate Rap1 (显示 TERF2IP 抗体)-mediated B-lymphocyte (显示 AKAP17A 抗体) adhesion.
HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion.
Hpk1 supports apoptosis of T lymphocytes by inhibiting the antiapoptotic action of NF-kappaB (显示 NFKB1 抗体) and inducing the proapoptotic activity of JNK (显示 MAPK8 抗体).
Mona/Gads (显示 GRAP2 抗体) SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix
suppression or activation of NFkappaB by HPK1 determines sensitivity to activation-induced cell death
HPK1-C as a suppressor of antiapoptotic Bcl-2 (显示 BCL2 抗体) proteins and provide a molecular basis for our understanding of CD95L (显示 FASL 抗体)-independent activation-induced cell death of lymphocytes.
Our data reveal a novel role for HPK1 as a negative regulator of dendritic cell functions
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation.
mitogen-activated protein kinase kinase kinase kinase 1
, MAPK/ERK kinase kinase kinase 1
, MEK kinase kinase 1
, MEKKK 1
, hematopoietic progenitor kinase 1
, mitogen activated protein kinase kinase kinase kinase 1