抗Human MALT1 抗体:
抗Mouse (Murine) MALT1 抗体:
抗Rat (Rattus) MALT1 抗体:
Human Polyclonal MALT1 Primary Antibody for WB - ABIN549013
Willis, Jadayel, Du, Peng, Perry, Abdul-Rauf, Price, Karran, Majekodunmi, Wlodarska, Pan, Crook, Hamoudi, Isaacson, Dyer: Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. in Cell 1999
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Human Monoclonal MALT1 Primary Antibody for IHC (p), WB - ABIN2475476
Pincus, Kahan, Mittal: A role for cAMP in the preparation of human platelets for the extraction of histocompatibility antigens. in Immunochemistry 1976
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Mouse (Murine) Polyclonal MALT1 Primary Antibody for ELISA, WB - ABIN4332478
Rosebeck, Madden, Jin, Gu, Apel, Appert, Hamoudi, Noels, Sagaert, Van Loo, Baens, Du, Lucas, McAllister-Lucas: Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. in Science (New York, N.Y.) 2011
Human Polyclonal MALT1 Primary Antibody for IHC, WB - ABIN6673467
Yang, Liu, Liu, Liu, Zhang, Wang, Jiang, Wang: miR-181d/MALT1 regulatory axis attenuates mesenchymal phenotype through NF-κB pathways in glioblastoma. in Cancer letters 2017
Data indicate the importance of "tuning" caspase recruitment domain family member 11 (CARD11 or CARMA1)-B cell CLL/lymphoma 10 (BCL10)-MALT1 paracaspase (MALT1) complex (CBM) signaling to preserve immune homeostasis [Review].
Long non-coding RNA MALAT1 sponged miR-195 to regulate proliferation, apoptosis and migration and immune escape abilities of DLBCL by regulation of PD-L1.
MALT1 paracaspase also targets MCPIP1 and degrade MCPIP1 protein in endothelial cells.
review of recent advances in the understanding of the molecular function of the protease MALT1 and summarize how MALT1 scaffold and protease function contribute to the transmission of CBM signals.
Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.
MALT1 activation by TRAF6 in lymphocytes needs neither BCL10 nor CARD11.
MALT1 C-terminal region covering the Ig2-paracaspase-Ig3 domain is flexibly attached to the BCL10-MALT N-terminal death domain core filaments
High MALT1 expression is associated with Breast Cancer.
Mutations in the translocated MALT1 allele is associated with IGH-MALT1-positive MALT lymphoma.
Cellular metabolism constrains innate immune responses in preterm infants due to perturbations in the expression of PPARgamma, MALT1, DDIT4, and most of the cytokines.
this first report show that MALT1 integrates several T-cell activation pathways and indirectly controls gamma-chain receptor dependent survival, to impact on T-cell expansion
These findings suggested that cleavage at R781 of MALT1 played a role in the survival of activated B-cell like diffuse large B-cell lymphoma cells.
MALT1 and TRAF6 cooperatively interact with CARMA1-BCL10 filaments and form CARMA1-BCL10-MALT1-TRAF6 signalosome.
The results suggest that the involvement of MALT1 in DNA damage-induced NF-kappaB is through the recruitment of TRAF6.
A missense mutation in mucosa-associated lymphoid tissue lymphoma translocation 1 gene (MALT1) was identified in a family with siblings with IPEX-Like Syndrome. MALT1 deficiency should now be considered as a possible cause of IPEX-like syndrome associated with immunodeficiency.
Thrombin-mediated MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage.
Authors utilized transcriptomic data and experimental evidences to prove that miR-181d was a novel regulator of NFkappaB signaling pathway by directly repressing MALT1, leading to induced PN markers and reduced MES genes.
Taken together, this present study indicates that miR-649 promotes herpes simplex virus type 1 replication through regulation of the MALT1-mediated antiviral signaling pathway and suggests a promising target for antiviral therapies.
These results demonstrate a key role for the proteolytic activity of MALT1 in PEL, and provide a rationale for the pharmacological targeting of MALT1 in PEL therapy.
MALT1 deficiency or pharmacological inhibition of MALT1 catalytic activity inhibits pathogenic mutant CARD14-induced cytokine and chemokine expression in human primary keratinocytes.
results demonstrate that partial disruption of the CBM complex and induction of IFNgamma secretion in the preferentially self-reactive Treg cell pool does not cause systemic autoimmunity but is sufficient to prime the tumour environment for successful immune checkpoint therapy
Malt1 protease activity plays an important role in the production of IL-17 in the blood and colon upon T cell receptor stimulation. In addition, Malt1 protease inactivation attenuates the development of experimental colitis with the regulation of the population of Th17 and Th1/17 cells.
These findings highlight the important regulatory role of MALT1 in the NF-kappaB-NFATc1-signalling axis during osteoclastogenesis and suggest that targeting MALT1 is a promising treatment option for rheumatoid arthritis.
CARD11-BCL10-MALT1 (CBM) signaling mediates TCR-induced NF-kappaB activation in Tregs and controls the conversion of resting Tregs to effector Tregs under homeostatic conditions. However, in inflammatory milieus, cytokines can bypass the CBM requirement for this differentiation step.
data presented here shows that Malt1 deficiency (Malt1-/-) exacerbates dextran sodium sulfate-induced inflammation
Malt1 self-cleavage is important in regulating expression of NF-kappaB target genes and subsequent T cell activation for anti-tumor immunity.
IKKbeta is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets.
this study shows that Malt1 protease activity plays an important role in the activation of innate immune cells via FcgammaR, and the development of FcgammaR-mediated autoimmune diseases
the importance of MALT1-mediated inflammation and T cell activation to control ERA virus, providing new insights in the biology of MALT1 and rabies virus infection.
MALT1 as a key molecule that contributes to immune tolerance at steady-state while facilitating immune reactivity under stress conditions.
Data show that inhibition of the protease activity of MALT1 might be a strategy to treat inflammatory bowel disease and the NLRP3 inflammasome and NF-kappaB activation are critical components in MALT1 signaling cascades in this disease model.
MALT1 function is required in B cells for germinal center formation.
Studies indicate an important role for mucosa associated lymphoid tissue lymphoma translocation gene 1 protein (MALT1) in the development of experimental autoimmune encephalomyelitis (EAE)
Targeting MALT1 proteolytic activity in autoimmune disease and B-cell lymphoma might not be a successful strategy. (Review)
TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
MALT1-dependent NF-kappaB activation is crucial for the development of EGFR-associated solid-tumor progression
By regulating linear ubiquitination, MALT1 is both a positive and negative pleiotropic regulator of the canonical NF-kappaB pathway.
Results demonstrate that MALT1 protease activity plays key roles in both innate and adaptive immune responses, and in regulating immune homeostasis in vivo.
data demonstrate that MALT1 ubiquitination is critical for the engagement of CBM and IKK complexes, thereby directing platelet signals to the NF-kappaB pathway.
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
mucosa associated lymphoid tissue lymphoma translocation gene 1
, mucosa associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1-like
, MALT associated translocation
, MALT lymphoma-associated translocation
, MALT-lymphoma associated translocation
, caspase-like protein
, mucosa-associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog