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抗Human MALT1 抗体:
抗Mouse (Murine) MALT1 抗体:
抗Rat (Rattus) MALT1 抗体:
Human Monoclonal MALT1 Primary Antibody for IHC (p), WB - ABIN2475476
Pincus, Kahan, Mittal: A role for cAMP in the preparation of human platelets for the extraction of histocompatibility antigens. in Immunochemistry 1976
Show all 3 Pubmed References
Mouse (Murine) Polyclonal MALT1 Primary Antibody for ELISA, WB - ABIN4332478
Rosebeck, Madden, Jin, Gu, Apel, Appert, Hamoudi, Noels, Sagaert, Van Loo, Baens, Du, Lucas, McAllister-Lucas: Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. in Science (New York, N.Y.) 2011
A missense mutation in mucosa-associated lymphoid tissue lymphoma translocation 1 gene (MALT1) was identified in a family with siblings with IPEX (显示 FOXP3 抗体)-Like Syndrome. MALT1 deficiency should now be considered as a possible cause of IPEX (显示 FOXP3 抗体)-like syndrome associated with immunodeficiency.
Thrombin (显示 F2 抗体)-mediated MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD (显示 CYLD 抗体) cleavage.
Authors utilized transcriptomic data and experimental evidences to prove that miR (显示 MLXIP 抗体)-181d was a novel regulator of NFkappaB (显示 NFKB1 抗体) signaling pathway by directly repressing MALT1, leading to induced PN markers and reduced MES (显示 ME1 抗体) genes.
Taken together, this present study indicates that miR (显示 MLXIP 抗体)-649 promotes herpes simplex virus type 1 replication through regulation of the MALT1-mediated antiviral signaling pathway and suggests a promising target for antiviral therapies.
These results demonstrate a key role for the proteolytic activity of MALT1 in PEL, and provide a rationale for the pharmacological targeting of MALT1 in PEL therapy.
MALT1 deficiency or pharmacological inhibition of MALT1 catalytic activity inhibits pathogenic mutant CARD14 (显示 CARD14 抗体)-induced cytokine and chemokine (显示 CCL1 抗体) expression in human primary keratinocytes.
results unveil HOIL1 (显示 RBCK1 抗体) as a negative regulator of lymphocyte activation cleaved by MALT1.
CARD14 (显示 CARD14 抗体)/MALT1-mediated signaling in keratinocytes has a role in psoriasis [review]
Psoriasis mutations disrupt CARD14 (显示 CARD14 抗体) autoinhibition promoting BCL10 (显示 BCL10 抗体)-MALT1-dependent NF-kappaB (显示 NFKB1 抗体) activation
Studies indicate that t(11;18)(q21;q21) translocation involves MALT1 (MALT lymphoma translocation protein 1) gene.
Data show that inhibition of the protease activity of MALT1 might be a strategy to treat inflammatory bowel disease and the NLRP3 (显示 NLRP3 抗体) inflammasome and NF-kappaB (显示 NFKB1 抗体) activation are critical components in MALT1 signaling cascades in this disease model.
MALT1 function is required in B cells for germinal center formation.
Studies indicate an important role for mucosa associated lymphoid tissue lymphoma translocation gene 1 protein (MALT1) in the development of experimental autoimmune encephalomyelitis (EAE)
Targeting MALT1 proteolytic activity in autoimmune disease and B-cell lymphoma might not be a successful strategy. (Review)
TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
MALT1-dependent NF-kappaB (显示 NFKB1 抗体) activation is crucial for the development of EGFR (显示 EGFR 抗体)-associated solid-tumor progression
By regulating linear ubiquitination, MALT1 is both a positive and negative pleiotropic regulator of the canonical NF-kappaB (显示 NFKB1 抗体) pathway.
Results demonstrate that MALT1 protease activity plays key roles in both innate and adaptive immune responses, and in regulating immune homeostasis in vivo.
data demonstrate that MALT1 ubiquitination is critical for the engagement of CBM and IKK (显示 CHUK 抗体) complexes, thereby directing platelet signals to the NF-kappaB (显示 NFKB1 抗体) pathway.
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
mucosa associated lymphoid tissue lymphoma translocation gene 1
, mucosa associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1-like
, MALT associated translocation
, MALT lymphoma-associated translocation
, MALT-lymphoma associated translocation
, caspase-like protein
, mucosa-associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog