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MALT1 抗体 (AA 701-808)

MALT1 适用: 人 WB, IHC (f) 宿主: 小鼠 Monoclonal MT1-410 unconjugated
产品编号 ABIN6939110
发货至: 中国
  • 抗原 See all MALT1 抗体
    MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))
    抗原表位
    • 19
    • 15
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    • 2
    • 1
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    AA 701-808
    适用
    • 64
    • 18
    • 14
    • 1
    宿主
    • 43
    • 22
    • 1
    小鼠
    克隆类型
    • 43
    • 23
    单克隆
    标记
    • 38
    • 3
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
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    This MALT1 antibody is un-conjugated
    应用范围
    • 53
    • 24
    • 17
    • 13
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    • 13
    • 12
    • 8
    • 8
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    特异性
    Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11,18)(q21,q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.
    交叉反应 (详细)
    Human,
    纯化方法
    200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
    免疫原
    Human MALT1 recombinant fragment (aa701-808)
    克隆位点
    MT1-410
    亚型
    IgG1
    Top Product
    Discover our top product MALT1 Primary Antibody
  • 应用备注

    Positive Control: Jurkat, Daudi or HeLa cells. Tonsil or lymphoma.

    Known Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    限制
    仅限研究用
  • 浓度
    200 μg/mL
    缓冲液
    Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-80 °C
    储存方法
    Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
    有效期
    24 months
  • 抗原
    MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))
    别名
    MALT1 (MALT1 产品)
    别名
    malt1 antibody, MALT1 antibody, mlt antibody, mlt1 antibody, MLT antibody, MLT1 antibody, A630046N12 antibody, D430033E09Rik antibody, MALT paracaspase 2 antibody, MALT1 paracaspase antibody, MALT1 paracaspase S homeolog antibody, paracaspase 3 antibody, malt2 antibody, MALT1 antibody, malt1.S antibody, Malt1 antibody, PCASP3 antibody
    背景
    Caspase-like protein, MALT lymphoma-associated translocation, MLT1, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Paracaspase,MALT1 (MALT-Lymphoma Marker)
    Cellular localisation: Cytoplasmic
    分子量
    93kDa
    基因ID
    10892, 601217
    UniProt
    Q9UDY8
    途径
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
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