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抗Human GRAP2 抗体:
抗Mouse (Murine) GRAP2 抗体:
抗Rat (Rattus) GRAP2 抗体:
Human Monoclonal GRAP2 Primary Antibody for FACS, IP - ABIN509570
Yankee, Draves, Ewings, Clark, Graves: CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling. in Proceedings of the National Academy of Sciences of the United States of America 2001
Show all 4 Pubmed References
Human Polyclonal GRAP2 Primary Antibody for ELISA, WB - ABIN256936
Qiu, Hua, Agrawal, Li, Cai, Chan, Zhou, Luo, Liu: Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. in Biochemical and biophysical research communications 1999
These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 (显示 LCP2 抗体) complex is required for costimulation by CD6 (显示 CD6 抗体).
Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2 (显示 GRB2 抗体)), Grb2 (显示 GRB2 抗体)-related adaptor downstream of Shc (显示 SHC1 抗体) (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (显示 SRC 抗体) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 (显示 CD28 抗体) with variable affinity
GADS deficient T cells displayed similar levels of T cell receptor -induced SLP-76 (显示 LCP2 抗体) and PLC-gamma1 (显示 PLCG1 抗体) phosphorylation but exhibited substantial decrease in TCR-induced IL-2 (显示 IL2 抗体) and IFN-gamma (显示 IFNG 抗体) release.
Gads was dispensable for TCR-induced phosphorylation of SLP-76 (显示 LCP2 抗体), but was a dose-dependent amplifier of TCR-induced CD69 (显示 CD69 抗体) expression.
GADS mediates lymphoid disease downstream of BCR-ABL (显示 ABL1 抗体) through the recruitment of specific signaling intermediates.
Histidine domain-protein tyrosine phosphatase (显示 ACP1 抗体) interacts with Grb2 (显示 GRB2 抗体) and GrpL
The results show that Bcr-Abl (显示 ABL1 抗体) regulates the actin cytoskeleton and non-apoptotic membrane blebbing via a GADS/Slp-76 (显示 LCP2 抗体)/Nck1 (显示 NCK1 抗体) adaptor protein pathway.
Exogenous expression of GrpL in a GrpL-negative B cell line leads to enhanced antigen receptor-induced extracellular signal-related kinase and p38 mitogen-activated protein kinase (显示 MAPK14 抗体) phosphorylation.
AML-1 (显示 RUNX1 抗体) plays a role in driving Mona (显示 MMP2 抗体) protein expression in T and myelomonocytic cells.
Plays a tissue-specific role as an inhibitor of RET receptor tyrosine kinase (显示 RET 抗体) mitogenic signaling
High GADS expression is associated with neoplasms.
The combined loss of Gads and CD127 (显示 IL7R 抗体) reveals a novel function of Gads prior to T cell receptor beta expression
Data show that the primary function of Gads is to regulate the sensitivity of the TCR to Ag ligation.
Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein (显示 GAB3 抗体) during monocyte/macrophage differentiation. (Gab3 scaffolding protein (显示 GAB3 抗体))
Results reveal the basis for preferential recognition of specific LAT (显示 LAT 抗体) sites by Gads.
Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1 (显示 MAP4K1 抗体)) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix
The Gads adaptor protein is critical for homeostasis of CD4 (显示 CD4 抗体)(+) T cells.
Selective impairment of FcepsilonRI (显示 FCER1A 抗体)-mediated allergic reaction in Gads-deficient mice
Gads plays a key role in linking the adapter LAT (显示 LAT 抗体) to SLP-76 (显示 LCP2 抗体) in response to weak activation of GPVI (显示 GP6 抗体) and CLEC-2 (显示 CLEC1B 抗体) whereas LAT (显示 LAT 抗体) is required for full activation over a wider range of agonist concentrations.
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.
GRB2-related adaptor protein 2
, GRB2-related adapter protein 2
, GRB-2-like protein
, GRB2-related protein with insert domain
, SH3-SH2-SH3 adapter Mona
, SH3-SH2-SH3 adaptor molecule
, adapter protein GRID
, grf40 adapter protein
, growth factor receptor-binding protein
, growth factor receptor-bound protein 2-related adaptor protein 2
, hematopoietic cell-associated adapter protein GrpL
, hematopoietic cell-associated adaptor protein GRPL
, GRB-2-related monocytic adapter protein
, Grb2-related adaptor downstream of Sch
, hematopoietic cell-associated adaptor protein GrpL
, monocytic adapter
, monocytic adaptor