(Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1))
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008].
Lajoie, Zijenah, Faucher, Ward, Roger: "Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases." in: Human immunology, Vol. 64, Issue 8, pp. 823-9, (2003) (PubMed).
Kim, Kataoka, Dreyfuss: "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex." in: Science (New York, N.Y.), Vol. 293, Issue 5536, pp. 1832-6, (2001) (PubMed).
Tang, Freedman, Allen, Karita, Musonda, Braga, Margolick, Kaslow: "TAPI polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies." in: Human immunology, Vol. 62, Issue 3, pp. 256-68, (2001) (PubMed).
Gaudet, Wiley: "Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing." in: The EMBO journal, Vol. 20, Issue 17, pp. 4964-72, (2001) (PubMed).
Aliases for TAP1 抗体
transporter 1, ATP binding cassette subfamily B member (TAP1) 抗体 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) L homeolog (tap1.L) 抗体 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (TAP1) 抗体 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (Tap1) 抗体 transporter 1, ATP binding cassette subfamily B member (Tap1) 抗体 ABC17 抗体 abc17 抗体 ABCB2 抗体 abcb2 抗体 Abcb2 抗体 APT1 抗体 apt1 抗体 Cim 抗体 D6S114E 抗体 Ham-1 抗体 Ham1 抗体 MTP1 抗体 PSF-1 抗体 PSF1 抗体 psf1 抗体 RING4 抗体 ring4 抗体 TAP 抗体 Tap-1 抗体 TAP1*0102N 抗体 tap1a 抗体 TAP1N 抗体 tap1n 抗体 Y3 抗体