TAB1 抗体
(TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| TAB1 抗体 (AA 3-100) | 人 | 小鼠 Monoclonal |
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| TAB1 抗体 (AA 205-504) | 人 | 兔 Polyclonal |
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| TAB1 抗体 (AA 205-504) | 人 | 兔 Polyclonal |
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| TAB1 抗体 (AA 1-504) | 人 | 小鼠 Monoclonal |
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| TAB1 抗体 (AA 601-712) | 人 | 兔 Polyclonal |
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| TAB1 抗体 | 人 | 兔 Monoclonal |
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| Recombinant TAB1 抗体 | 人 | 兔 Monoclonal |
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| TAB1 抗体 | 人 | 兔 Polyclonal |
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| TAB1 抗体 (AA 1-504) | 人 | 小鼠 Polyclonal |
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| TAB1 抗体 (pSer423) | 人 | 兔 Polyclonal |
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| TAB1 抗体 (N-Term) | 人, 小鼠, 大鼠, Pig, 兔, 小鸡, 猴 | 兔 Polyclonal |
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| TAB1 抗体 (N-Term) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| TAB1 抗体 (C-Term) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| TAB1 抗体 (AA 401-430) | 人 | 兔 Polyclonal |
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| TAB1 抗体 (AA 416-445) | 人 | 兔 Polyclonal |
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| TAB1 抗体 (AA 1-504) | 人 | 兔 Polyclonal |
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| TAB1 抗体 (AA 601-712) (Cy7) | 人 | 兔 Polyclonal |
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| TAB1 抗体 (AA 601-712) (FITC) | 人 | 兔 Polyclonal |
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| TAB1 抗体 (AA 601-712) (HRP) | 人 | 兔 Polyclonal |
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| TAB1 抗体 (AA 601-712) (Cy5) | 人 | 兔 Polyclonal |
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Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- PLA (Proximity Ligation Assay: 有验证图片)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 2A12
- 标记
- unconjugated
- 抗体亚型
- IgG1
- 抗原表位
- AA 3-100
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 205-504
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- IP (Immunoprecipitation: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 205-504
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 2G9
- 标记
- unconjugated
- 抗体亚型
- IgG1 kappa
- 抗原表位
- AA 1-504
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- IHC (fro) (Immunohistochemistry (Frozen Sections): 所列应用)
2 references - 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 601-712
Primary Antibody
- WB (Western Blotting: 有验证图片)
- FACS (Flow Cytometry: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Monoclonal
- 克隆
- 24GB2570
- 标记
- unconjugated
- 蛋白类型
- Recombinant Antibody
- 抗体亚型
- IgG
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 1-504
Primary Antibody
- DB (Dot Blot: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 克隆
- RB21994
- 标记
- unconjugated
- 抗体亚型
- Ig Fraction
- 抗原表位
- pSer423
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- N-Term
Primary Antibody
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 克隆
- RB12711
- 标记
- unconjugated
- 抗体亚型
- Ig Fraction
- 抗原表位
- AA 401-430
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 克隆
- RB12875
- 标记
- unconjugated
- 抗体亚型
- Ig Fraction
- 抗原表位
- AA 416-445
Primary Antibody
- IP (Immunoprecipitation: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 1-504
Primary Antibody
- WB (Western Blotting: 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Cy7
- 抗体亚型
- IgG
- 抗原表位
- AA 601-712
Primary Antibody
- WB (Western Blotting: 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- FITC
- 抗体亚型
- IgG
- 抗原表位
- AA 601-712
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- IHC (fro) (Immunohistochemistry (Frozen Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- HRP
- 抗体亚型
- IgG
- 抗原表位
- AA 601-712
Primary Antibody
- WB (Western Blotting: 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Cy5
- 抗体亚型
- IgG
- 抗原表位
- AA 601-712
Latest Publications for our TAB1 抗体
: "MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected by Mycobacterium avium subspecies paratuberculosis by Targeting Interleukin-10 and TGF-β-Activated Protein Kinase 1 ..." in: Frontiers in immunology, Vol. 8, pp. 1915, (2017) (PubMed).
: "PRAK is essential for ras-induced senescence and tumor suppression." in: Cell, Vol. 128, Issue 2, pp. 295-308, (2007) (PubMed).
: "Determinants that control the specific interactions between TAB1 and p38alpha." in: Molecular and cellular biology, Vol. 26, Issue 10, pp. 3824-34, (2006) (PubMed).
: "TAK1-binding protein 1 is a pseudophosphatase." in: The Biochemical journal, Vol. 399, Issue 3, pp. 427-34, (2006) (PubMed).
: "Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex ..." in: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 7359-68, (2005) (PubMed).
: "Toll-like receptor signalling." in: Nature reviews. Immunology, Vol. 4, Issue 7, pp. 499-511, (2004) (PubMed).
: "Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol." in: Molecular and cellular biology, Vol. 22, Issue 20, pp. 7158-67, (2002) (PubMed).
: "TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages." in: FEBS letters, Vol. 467, Issue 2-3, pp. 160-4, (2000) (PubMed).
: "PRAK is essential for ras-induced senescence and tumor suppression." in: Cell, Vol. 128, Issue 2, pp. 295-308, (2007) (PubMed).
: "Determinants that control the specific interactions between TAB1 and p38alpha." in: Molecular and cellular biology, Vol. 26, Issue 10, pp. 3824-34, (2006) (PubMed).
: "TAK1-binding protein 1 is a pseudophosphatase." in: The Biochemical journal, Vol. 399, Issue 3, pp. 427-34, (2006) (PubMed).
: "Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex ..." in: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 7359-68, (2005) (PubMed).
: "Toll-like receptor signalling." in: Nature reviews. Immunology, Vol. 4, Issue 7, pp. 499-511, (2004) (PubMed).
: "Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol." in: Molecular and cellular biology, Vol. 22, Issue 20, pp. 7158-67, (2002) (PubMed).
: "TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages." in: FEBS letters, Vol. 467, Issue 2-3, pp. 160-4, (2000) (PubMed).
Aliases for TAB1 抗体
TGF-beta activated kinase 1 (MAP3K7) binding protein 1 (TAB1) 抗体TGF-beta activated kinase 1/MAP3K7 binding protein 1 (Tab1) 抗体
3'-Tab1 抗体
2310012M03Rik 抗体
b2b449Clo 抗体
MAP3K7IP1 抗体
Map3k7ip1 抗体
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