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Human Polyclonal PROX1 Primary Antibody for IF, WB - ABIN1589859
Quagliata, Klusmeier, Cremers, Pytowski, Harvey, Pettis, Thiele, Sleeman: Inhibition of VEGFR-3 activation in tumor-draining lymph nodes suppresses the outgrowth of lymph node metastases in the MT-450 syngeneic rat breast cancer model. in Clinical & experimental metastasis 2014
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Human Polyclonal PROX1 Primary Antibody for IHC (p), ELISA - ABIN542882
Nagai, Li, Hatano, Toshihito, Yuge, Ito, Utsumi, Saito, Kinoshita: Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies. in Genes, chromosomes & cancer 2003
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Human Polyclonal PROX1 Primary Antibody for WB - ABIN1881686
Hong, Harvey, Noh, Schacht, Hirakawa, Detmar, Oliver: Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. in Developmental dynamics : an official publication of the American Association of Anatomists 2002
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Human Polyclonal PROX1 Primary Antibody for IHC (p), ELISA - ABIN542883
Dyer, Livesey, Cepko, Oliver: Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. in Nature genetics 2003
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Human Polyclonal PROX1 Primary Antibody for IF, IHC (p) - ABIN929458
Kulkarni, Herman, Ikegami, Greenberg, Akeson: Lymphatic ontogeny and effect of hypoplasia in developing lung. in Mechanisms of development 2011
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Human Monoclonal PROX1 Primary Antibody for ICC, IF - ABIN2668929
Chen, Patel, Cain, Duncan: Production of monoclonal antibodies against Prox1. in Hybridoma (2005) 2006
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Human Polyclonal PROX1 Primary Antibody for ICC, IF - ABIN4347959
Abdolazimi, Stojanova, Segil: Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter. in Development (Cambridge, England) 2016
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Chicken Monoclonal PROX1 Primary Antibody for CyTOF, ELISA - ABIN447455
Sweat, Sloas, Murfee: VEGF-C induces lymphangiogenesis and angiogenesis in the rat mesentery culture model. in Microcirculation (New York, N.Y. : 1994) 2014
PROX1 expression was detected in gastric cancer tissues at various levels. PROX1 expression levels were positively correlated with cancer stage, N factor, lymphatic vascular invasion, and vascular invasion in patients with gastric cancer.
The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to lymph endothelial cells retraction.
Prox1 is a critical transcription factor for the differentiation of myoblasts via bi-directional crosstalk with Notch1.
PROX1 is a new prognostic biomarker for 1p19q non-codeleted high-grade astrocytomas that have progressed from pre-existing low-grade tumors and harbor IDH mutations.
ERbeta in both normal and cancerous colon epithelial cells upregulates miRNA-205, which subsequently reduces PROX1 through direct interaction with its 3'UTR
The aim of this study was to examine the association between HHEX (rs5015480) and PROX1 (rs340874) gene polymorphisms and Gestational diabetes mellitus (GDM) .Despite these associations, PROX1 gene variants were not previously examined in women with GDM; however, our results suggest a lack of such an association.
PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.
crucial promoter of hepatocellular carcinoma angiogenesis
study achieved a long-lasting expression of Prox1 in lymphatic endothelial-like cells, and it provided a potentially useful approach for developing novel therapies for limb lymphedema and lymphatic system-related diseases
In gastric cancer, high cytoplasmic PROX1 expression is an independent marker of better prognosis.
High PROX1 and beta-catenin expression were independent factors for better prognosis in pancreatic ductal adenocarcinoma.
Data suggest that DBC1 has a dual function in regulating beta-catenin-PROX1 signaling axis: as a coactivator for both beta-catenin and PROX1.
PROX1 gene is a strong candidate of early onset of diabetes with variations depending on ethnicity.
We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 rs17764730, PSMB5 rs941718), and hematocrit (PROX1 rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant
PROX1 serves an oncogenic role in glioblastoma multiforme and promotes cell proliferation and invasiveness potentially via activation of the NFkappa B signaling pathway.
High PROX1 expression is associated with gastric cancer.
High PROX1 expression is associated with Esophageal Squamous Cell Carcinoma.
Reduced expression of Prox1 is beneficial for the expansion and maturation of beta-cells.
PROX1 is an important regulator of endocrine secretory granule formation in medullary thyroid cancer cells.
Findings demonstrate that NOTCH-induced PROX1 inactivation significantly promotes the malignant behavior of thyroid carcinoma.
Prox1 was transiently expressed in the presumptive hair cells of the vestibular and auditory sensory organs.
Findings indicate that prospero homeobox 1 (Prox1) regulated the differentiation of oligodendrocyte precursor cells via the regulation of phorbol-12-myristate-13-acetate-induced protein 1 (NOXA).
the embryonic dermal blood capillary plexus constitutes a local source of embryonic lymphatic endothelial cells that contributes to the formation of the dermal lymphatic vascular network. Rare PROX1-positive endothelial cells exit the capillary plexus in a Ccbe1-dependent manner to establish discrete embryonic lymphatic endothelial cell clusters.
PROX1 controls expression of genes regulating lipid homeostasis.HDAC3 interacts with PROX1.
the neurogenic and oligodendrogliogenic lineages in the two adult neurogenic niches exhibit a distinct requirement for Prox1.
Our study demonstrates that Prox1-GFP/Flk1::myr-mCherry mice are a useful model for studying coordinated hemangiogenic and lymphangiogenic responses
Prox1 was first expressed in all developing neurons, followed by a decrease in type II primary auditory neurons as they matured.
Data indicate that prospero-related homeobox 1 (Prox1) has a role in regulating energy homeostasis in hepatocytes.
These results are the first demonstration that Prox1 activity protects pancreatic cells from acute tissue damage and early neoplastic transformation. Additional data in our study indicate that this novel role of Prox1 involves suppression of pathways associated with inflammatory responses and cell invasiveness.
the data show that Prox1 regulates proliferation and differentiation of the oligodendrocyte cell lineage, and is a relevant component of the endogenous regenerative response to Central nervous system injury.
Prox1 upregulation reduces proliferation, impairs maturation, and enables apoptosis in postnatal beta-cells. Prox1 overexpression causes MafA deficiency in beta-cells.
The PROX1-mediated repression is weakened or lost, thereby facilitating the induction of Reverse cholesterol transport genes and diminishing the progression of atherosclerosis
suggest that Prox1 appears to be a critical stage specific regulator of specifying ascending thin limb cell fate and that its expression is regulated by osmolality
we demonstrate that Prox1 and Asap1 behave as negative regulators of mammary stem/progenitor function. Both of these genes have also been implicated in oncogenesis.
Prox1 is made in postmitotic CGE-derived cortical interneuron precursors. It is differentially required during embryonic and postnatal stages for migration, differentiation, circuit integration, and maintenance programs in subtypes of these interneurons.
Sox2 was not restricted to developing taste bud cells expressing Prox1 during circumvallate development.
Expression of fluorescent Prox-1 allows functional characterization of Schlemm's canal.
Overall, the data show that HHEX controls blood vessel and lymphatic vessel formation by regulating the VEGFC/FLT4/PROX1 signaling axis.
using a transgenic reporter line, we show that prox1a is initially expressed in different endothelial compartments, becoming restricted to lymphatic endothelial cells only at later stages
Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.
Prox1 functions as a tissue-specific coregulator of Ff1b
Our findings indicate that prox1 activity is crucial for the proper development of the otp1-positive hypothalamic neuronal precursors to their terminal CA phenotype
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants.
prospero homeobox 1
, prospero homeobox protein 1-like
, Prox 1
, prospero-related homeobox 1
, homeobox prospero-like protein PROX1
, prospero homeobox protein 1
, prospero-related homeobox gene 1