anti-Prospero Homeobox 1 (PROX1) 抗体产品概述

Human Prospero Homeobox 1 (PROX1) interaction partners

1. PROX1 is a new prognostic biomarker for 1p19q non-codeleted high-grade astrocytomas that have progressed from pre-existing low-grade tumors and harbor IDH mutations.

2. ERbeta (显示 ESR2 抗体) in both normal and cancerous colon epithelial cells upregulates miRNA-205, which subsequently reduces PROX1 through direct interaction with its 3'UTR (显示 UTS2R 抗体)

3. The aim of this study was to examine the association between HHEX (显示 HHEX 抗体) (rs5015480) and PROX1 (rs340874) gene polymorphisms and Gestational diabetes mellitus (GDM) .Despite these associations, PROX1 gene variants were not previously examined in women with GDM; however, our results suggest a lack of such an association.

4. PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.

5. study achieved a long-lasting expression of Prox1 in lymphatic endothelial-like cells, and it provided a potentially useful approach for developing novel therapies for limb lymphedema and lymphatic system-related diseases

6. In gastric cancer, high cytoplasmic PROX1 expression is an independent marker of better prognosis.

7. High PROX1 and beta-catenin (显示 CTNNB1 抗体) expression were independent factors for better prognosis in pancreatic ductal adenocarcinoma.

8. Data suggest that DBC1 has a dual function in regulating beta-catenin (显示 CTNNB1 抗体)-PROX1 signaling axis: as a coactivator for both beta-catenin (显示 CTNNB1 抗体) and PROX1.

9. PROX1 gene is a strong candidate of early onset of diabetes with variations depending on ethnicity.

10. We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 (显示 SLC12A2 抗体) rs17764730, PSMB5 (显示 PSMB5 抗体) rs941718), and hematocrit (PROX1 rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant

Mouse (Murine) Prospero Homeobox 1 (PROX1) interaction partners

1. the embryonic dermal blood capillary plexus constitutes a local source of embryonic lymphatic endothelial cells that contributes to the formation of the dermal lymphatic vascular network. Rare PROX1 (显示 C16orf35 抗体)-positive endothelial cells exit the capillary plexus in a Ccbe1 (显示 CCBE1 抗体)-dependent manner to establish discrete embryonic lymphatic endothelial cell clusters.

2. PROX1 (显示 C16orf35 抗体) controls expression of genes regulating lipid homeostasis.HDAC3 interacts with PROX1 (显示 C16orf35 抗体).

3. the neurogenic and oligodendrogliogenic lineages in the two adult neurogenic niches exhibit a distinct requirement for Prox1 (显示 C16orf35 抗体).

4. PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.

5. Our study demonstrates that Prox1 (显示 C16orf35 抗体)-GFP/Flk1 (显示 KDR 抗体)::myr-mCherry mice are a useful model for studying coordinated hemangiogenic and lymphangiogenic responses

6. Prox1 (显示 C16orf35 抗体) was first expressed in all developing neurons, followed by a decrease in type II primary auditory neurons as they matured.

7. Data indicate that prospero-related homeobox 1 (Prox1) has a role in regulating energy homeostasis in hepatocytes.

8. These results are the first demonstration that Prox1 (显示 C16orf35 抗体) activity protects pancreatic cells from acute tissue damage and early neoplastic transformation. Additional data in our study indicate that this novel role of Prox1 (显示 C16orf35 抗体) involves suppression of pathways associated with inflammatory responses and cell invasiveness.

9. the data show that Prox1 (显示 C16orf35 抗体) regulates proliferation and differentiation of the oligodendrocyte cell lineage, and is a relevant component of the endogenous regenerative response to Central nervous system injury.

10. Prox1 (显示 C16orf35 抗体) upregulation reduces proliferation, impairs maturation, and enables apoptosis in postnatal beta-cells. Prox1 (显示 C16orf35 抗体) overexpression causes MafA (显示 MAFA 抗体) deficiency in beta-cells.

Zebrafish Prospero Homeobox 1 (PROX1) interaction partners

1. using a transgenic reporter line, we show that prox1a is initially expressed in different endothelial compartments, becoming restricted to lymphatic endothelial cells only at later stages

2. Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.

3. Prox1 functions as a tissue-specific coregulator of Ff1b

4. Our findings indicate that prox1 activity is crucial for the proper development of the otp1 (显示 OTOP1 抗体)-positive hypothalamic neuronal precursors to their terminal CA phenotype