(Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
signal transducer and activator of transcription 1 (STAT1) 蛋白 signal transducer and activator of transcription 1 (Stat1) 蛋白 signal transducer and activator of transcription 1 L homeolog (stat1.L) 蛋白 signal transducer and activator of transcription 1, 91kDa (STAT1) 蛋白 signal transducer and activator of transcription 4 (stat4) 蛋白 signal transducer and activator of transcription 1a (stat1a) 蛋白 2010005J02Rik 蛋白 AA408197 蛋白 CANDF7 蛋白 DD6G4-4 蛋白 dZ182H3.3 蛋白 ISGF-3 蛋白 si:by51f19.1 蛋白 si:by134g18.2 蛋白 si:dz73o4.2 蛋白 si:dz182h3.3 蛋白 si:dz199m19.1 蛋白 STAT 蛋白 STAT1 蛋白 stat1 蛋白 STAT4 蛋白 STAT91 蛋白 XStat1 蛋白