Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase. [provided by RefSeq, Jul 2008].
Schmid, Lambertini, van Vugt, Barzaghi-Rinaudo, Schäfer, Hillenbrand, Sailer, Kaufmann, Nuciforo: "Monoclonal antibodies against the human somatostatin receptor subtypes 1-5: development and immunohistochemical application in neuroendocrine tumors." in: Neuroendocrinology, Vol. 95, Issue 3, pp. 232-47, (2012) (PubMed).