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Sonic Hedgehog 蛋白

(Sonic Hedgehog (SHH))
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008].
Sonic Hedgehog (SHH) (AA 24-197), (Cys24IleIle-Mutant) (Active) protein Sonic Hedgehog (SHH) (AA 24-197), (Cys24IleIle-Mutant) (Active) protein Sonic Hedgehog (SHH) (AA 24-197), (Cys24IleIle-Mutant) (Active) protein (ABIN2018361)

SHH 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % by SDS-PAGE and HPLC analyses. Active

Sonic Hedgehog (SHH) (AA 25-198), (Cys25IleIle-Mutant) (Active) protein Sonic Hedgehog (SHH) (AA 25-198), (Cys25IleIle-Mutant) (Active) protein Sonic Hedgehog (SHH) (AA 25-198), (Cys25IleIle-Mutant) (Active) protein (ABIN2018373)

SHH 宿主: 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % by SDS-PAGE and HPLC analyses. Active

Sonic Hedgehog (SHH) (AA 24-197) protein (His tag) Sonic Hedgehog (SHH) (AA 24-197) protein (His tag) Sonic Hedgehog (SHH) (AA 24-197) protein (His tag) (ABIN2181760)

SHH 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.

Sonic Hedgehog 蛋白 by Grade

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Sonic Hedgehog 蛋白 by Origin

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Popular Sonic Hedgehog 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3077106
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3077105
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3123150
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3123152
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3077104
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN6700560
Quantity 5 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN666981
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319947
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN2967699
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2732359
Quantity 20 μg
Datasheet Datasheet
Reactivity Mouse
Source CHO Cells
Validations
Cat. No. ABIN2018370
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN1097559
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7125172
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7089028
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7089027
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our Sonic Hedgehog 蛋白

Kaushal, Popli, Sankhwar, Shukla, Dwivedi: "Sonic hedgehog protects endometrial hyperplasial cells against oxidative stress via suppressing mitochondrial fission protein dynamin-like GTPase (Drp1)." in: Free radical biology & medicine, Vol. 129, pp. 582-599, (2018) (PubMed).

Aliases for Sonic Hedgehog 蛋白

sonic hedgehog (SHH) 蛋白
sonic hedgehog (Shh) 蛋白
sonic hedgehog a (shha) 蛋白
sonic hedgehog L homeolog (shh.L) 蛋白
sonic hedgehog (shh) 蛋白
sonic hedgehog protein A (shh) 蛋白
sonic hedgehog b (shhb) 蛋白
9530036O11Rik 蛋白
Dsh 蛋白
fc83d08 蛋白
hedgehog 蛋白
HHG1 蛋白
Hhg1 蛋白
HLP3 蛋白
HPE3 蛋白
Hx 蛋白
Hxl3 蛋白
M100081 蛋白
MCOPCB5 蛋白
shh 蛋白
SHH 蛋白
SMMCI 蛋白
syu 蛋白
TPT 蛋白
TPTPS 蛋白
twh 蛋白
twhh 蛋白
vhh-1 蛋白
vhh1 蛋白
wu:fc83d08 蛋白
Xhh 蛋白
xshh 蛋白
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