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SMURF2 蛋白

(SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).

8 results :

custom-made SMURF2 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7555579
 
custom-made SMURF2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7561867
 
SMURF2 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant SDS, ELISA, WB
产品编号 ABIN7579604
 
custom-made SMURF2 宿主: 小鼠 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, ELISA, WB
产品编号 ABIN3130681
 
custom-made SMURF2 宿主: 人 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, ELISA, WB
产品编号 ABIN3095583
 
SMURF2 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % SDS
产品编号 ABIN5711831
 
SMURF2 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
产品编号 ABIN5714482
 
SMURF2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2732271
 
  • 类型 Protein
    • Protein
  • 应用范围
    • SDS-PAGE (SDS)
    • ELISA
    • Western Blotting (WB)
    • Antibody Production (AbP)
    • Standard (STD)
  • 适用
    • Human
    • Mouse
  • 图像
  • Carrier free only
  • 抗体来源
    • HEK-293 Cells
    • Cell-free protein synthesis (CFPS)
    • Escherichia coli (E. coli)
    • Yeast
  • 抗原表位
    • AA 1-748
    • full length
  • 标记
    • His tag
    • Strep Tag
    • GST tag
    • Myc-DYKDDDDK Tag
  • 蛋白类型
    • Recombinant
  • Format
    • Liquid
    • Lyophilized
  • Grade
    • custom-made
  • Supplier
    • antibodies-online
    • Signalway
    • OriGene

Aliases for SMURF2 蛋白

SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) 蛋白
SMAD specific E3 ubiquitin protein ligase 2 (smurf2) 蛋白
SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) 蛋白
SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S) 蛋白
2810411E22Rik 蛋白
AI558114 蛋白
AI649275 蛋白
RGD1310067 蛋白
SMURF2 蛋白
wu:fb82a11 蛋白
wu:fc41c02 蛋白
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