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SMN1 蛋白

(Survival of Motor Neuron 1, Telomeric (SMN1))
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy\; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Sep 2008].
Survival of Motor Neuron 1, Telomeric (SMN1) (AA 1-288) protein (His tag) Survival of Motor Neuron 1, Telomeric (SMN1) (AA 1-288) protein (His tag) Survival of Motor Neuron 1, Telomeric (SMN1) (AA 1-288) protein (His tag) (ABIN3134732)

Crystallography grade SMN1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB

Survival of Motor Neuron 1, Telomeric (SMN1) (AA 1-140) protein (GST tag) Survival of Motor Neuron 1, Telomeric (SMN1) (AA 1-140) protein (GST tag) Survival of Motor Neuron 1, Telomeric (SMN1) (AA 1-140) protein (GST tag) (ABIN1320585)

SMN1 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB

Survival of Motor Neuron 1, Telomeric (SMN1) (AA 49-140) protein (GST tag) Survival of Motor Neuron 1, Telomeric (SMN1) (AA 49-140) protein (GST tag) Survival of Motor Neuron 1, Telomeric (SMN1) (AA 49-140) protein (GST tag) (ABIN1320589)

SMN1 宿主: 人 宿主: 小麦胚 Recombinant AP, AA, ELISA, WB

SMN1 蛋白 by Grade

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SMN1 蛋白 by Origin

Find SMN1 蛋白 for a variety of species such as anti-Human SMN1, anti-Cat SMN1, anti-Cow SMN1. The species listed below are among those available. Click on a link to go to the corresponding products.

SMN1 蛋白 by Source

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SMN1 蛋白 by 蛋白类型

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SMN1 蛋白 by 应用范围

Find SMN1 蛋白 validated for a specific application such as ELISA, WB, AP, AA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular SMN1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7089282
Quantity 50 μg
Datasheet Datasheet
Reactivity Cow
Source Yeast
Validations
Cat. No. ABIN1460985
Quantity 1 mg
Datasheet Datasheet
Reactivity Dog
Source Yeast
Validations
Cat. No. ABIN1461410
Quantity 1 mg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1475468
Quantity 1 mg
Datasheet Datasheet
Reactivity Cat
Source Yeast
Validations
Cat. No. ABIN1636281
Quantity 1 mg
Datasheet Datasheet
Reactivity Cynomolgus
Source Yeast
Validations
Cat. No. ABIN1631650
Quantity 1 mg
Datasheet Datasheet

Aliases for SMN1 蛋白

survival motor neuron protein (LOC461829) 蛋白
survival of motor neuron 1, telomeric (Smn1) 蛋白
survival of motor neuron 1, telomeric (SMN1) 蛋白
survival motor neuron 1 (Smn1) 蛋白
survival of motor neuron 2, centromeric (SMN2) 蛋白
survival motor neuron protein-like (LOC100348318) 蛋白
survival motor neuron (SMN) 蛋白
survival motor neuron protein (LOC100713418) 蛋白
survival motor neuron protein (LOC100065744) 蛋白
survival motor neuron protein (LOC102176643) 蛋白
survival of motor neuron 1, telomeric (smn1) 蛋白
AI849087 蛋白
BCD541 蛋白
fa12d01 蛋白
GEMIN1 蛋白
Gemin1 蛋白
QtsA-10002 蛋白
SMA 蛋白
SMA1 蛋白
SMA2 蛋白
SMA3 蛋白
SMA4 蛋白
SMA@ 蛋白
Smn 蛋白
SMN 蛋白
smn 蛋白
SMN1 蛋白
SMN2 蛋白
SMNT 蛋白
T-BCD541 蛋白
TDRD16A 蛋白
wu:fa12d01 蛋白
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