(Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2))
This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Theisen, Wahl, Johnson, Wheelock: "NHERF links the N-cadherin/catenin complex to the platelet-derived growth factor receptor to modulate the actin cytoskeleton and regulate cell motility." in: Molecular biology of the cell, Vol. 18, Issue 4, pp. 1220-32, (2007) (PubMed).
Cha, Kim, Hut, Hogema, Nadarja, Zizak, Cavet, Lee-Kwon, Lohmann, Smolenski, Tse, Yun, de Jonge, Donowitz: "cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein." in: The Journal of biological chemistry, Vol. 280, Issue 17, pp. 16642-50, (2005) (PubMed).