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High DOCK1 expression is associated with Oral squamous cell carcinoma.
Dock1 modulation by miR (显示 MLXIP 蛋白)-31 plays an important function in glioma invasion
In summary, this investigation identifies an EGFR (显示 EGFR 蛋白)-DOCK180-RAC1-MLK3 (显示 MAP3K11 蛋白)-JNK (显示 MAPK8 蛋白) signaling axis that drives glioblastoma cell migration and dissemination.IMPLICATIONS: On the basis of these findings, MLK3 (显示 MAP3K11 蛋白) emerges as a potential therapeutic target for the treatment of glioblastoma
one statistically significant common variant in the DOCK1 gene was associated with DeltaBMI in GI cancer and COPD (显示 ARCN1 蛋白) cases providing support for at least partially shared aetiology of DeltaBMI in complex diseases.
Taken together, these results indicate that DOCK1 is a critical regulator of the malignant phenotypes induced by Rac1(P29S), and suggest that targeting DOCK1 might be an effective approach to treat cancers associated with Rac1(P29S) mutation.
Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1 (显示 ELMO1 蛋白)-Dock180 and intersectin 1 (显示 ITSN1 蛋白)/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 (显示 ELMO1 蛋白) = ELMO domain-containing protein 1 (显示 ELMOD1 蛋白); Dock180 = dedicator of cytokinesis protein 1 180 kDa)
stimulation of the DOCK180 pathway represents an alternative mechanism of PTP1B (显示 PTPN1 蛋白) inhibitor-stimulated endothelial cell motility, which does not require concomitant VEGFR2 (显示 KDR 蛋白) activation as a prerequisite.
Thus, Elmo1 (显示 ELMO1 蛋白) and Dock180 facilitate blood vessel formation by stabilization of the endothelium during angiogenesis.
High DOCK180 expression is associated with serous ovarian cancer.
our findings describe a novel mechanism by which EGFRvIII drives glioma tumorigenesis and invasion through protein kinase A-dependent phosphorylation of Dock180
Inactivation of Dock1 in mammary gland epithelial cells and activation of Stat3 (显示 STAT3 蛋白) coincide with a delay in the initiation of mammary gland involution.
Dock1 and Dock5 are not the important exchange factors regulating Rac (显示 AKT1 蛋白) activity during the establishment and maintenance of the glomerular barrier
DOCK1-Rac (显示 AKT1 蛋白) signaling as an HER2 (显示 ERBB2 蛋白) effector pathway essential for HER2 (显示 ERBB2 蛋白)-mediated breast cancer progression to metastasis.
The phospholipase D-PA axis selectively controls dorsal ruffle formation by regulating DOCK1 localization.
The data demonstrate the ability of the SH3 domain (显示 ITSN1 蛋白) of DOCK180 to interact with ELMO1 (显示 ELMO1 蛋白), regardless of the presence of the polyproline-containing C-terminal end.
Dock1 has an essential role in embryonic development.
Results indicate that the combination of DOCK2 and DOCK180 plays a significant but not essential role in prevascular fetal thymus colonization.
A novel signaling cascade is identified in which ELMO1 (显示 ELMO1 蛋白)/DOCK180 regulates vasculature formation in zebrafish.
The fusion of embryonic fast-twitch myoblasts requires the activities of Dock1 and the closely related Dock5 protein.
This gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis.
180 kDa protein downstream of CRK
, DOwnstream of CrK
, dedicator of cyto-kinesis 1
, dedicator of cytokinesis protein 1
, dedicator of cytokinesis 1
, dedicator of cytokinesis protein 1-like