(Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).
custom-made
SIGIRR
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
custom-made
SIGIRR
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, SDS, ELISA
single Ig and TIR domain containing (SIGIRR) 蛋白 single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr) 蛋白 single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (sigirr) 蛋白 single Ig and TIR domain containing (Sigirr) 蛋白 AI256711 蛋白 RGD1306732 蛋白 sc:d148 蛋白 TIR8 蛋白