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Septin 2 产品

(Septin 2 (SEPT2))

Categories

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity).

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Featured Septin 2 Categories

Septin 2 抗体

High quality antibodies with extensive validation data.

Septin 2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Septin 2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (4)
Cat. No. ABIN308439
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (3)
Cat. No. ABIN518271
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7168865
Quantity 100 μg
Datasheet Datasheet

Recommended Septin 2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6975081
Quantity 96 tests
Datasheet Datasheet

Recommended Septin 2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125024
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319544
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319542
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Septin 2 Products

James, Cantillo, Yano, Chichester, DiSilvestro, Hovanesian, Rao, Kim, Moore, Ahsan, Ribeiro: "Septin-2 is overexpressed in epithelial ovarian cancer and mediates proliferation via regulation of cellular metabolic proteins." in: Oncotarget, Vol. 10, Issue 31, pp. 2959-2972, (2019) (PubMed).

Dolat, Spiliotis: "Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion." in: The Journal of cell biology, Vol. 214, Issue 5, pp. 517-27, (2016) (PubMed).

Volceanov, Herbst, Biniossek, Schilling, Haller, Nölke, Subbarayal, Rudel, Zieger, Häcker: "Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion." in: mBio, Vol. 5, Issue 5, pp. e01802-14, (2014) (PubMed).

Froidevaux-Klipfel, Poirier, Boursier, Crépin, Poüs, Baudin, Baillet: "Modulation of septin and molecular motor recruitment in the microtubule environment of the Taxol-resistant human breast cancer cell line MDA-MB-231." in: Proteomics, Vol. 11, Issue 19, pp. 3877-86, (2011) (PubMed).

Kremer, Adang, Macara: "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7." in: Cell, Vol. 130, Issue 5, pp. 837-50, (2007) (PubMed).

Synonyms and alternative names related to Septin 2

septin 2 (SEPT2), septin 2 (Sept2), septin 2 (sept2), septin 2 L homeolog (sept2.L), septin 2-like (SEPT2L), COG1487; VapC; putative nucleic acid-binding protein; contains PIN domain (sepT2), septin 2 S homeolog (sept2.S), AW208991, DIFF6, diff6, hNedd5, hnedd5, mKIAA0158, Nedd-5, NEDD5, Nedd5, nedd5, Pnutl3, pnutl3, Sep-02, sept2, SEPT2, sept2-B, septa, Septin-2, Septin-2A, Septin-2B, Septin-A, Vesp11, wu:fb52g01, wu:fb99a01, xlsepta

Protein level used designations for Septin 2

  • NEDD-5
  • neural precursor cell expressed developmentally down-regulated protein 5
  • neural precursor cell expressed, developmentally down-regulated 5
  • septin-2
  • neural precursor cell expressed, developmentally down-regulated gene 5
  • vascular endothelial cell specific protein 11
  • septin A
  • septin-2A
  • septin 2
  • ANL34
  • septin-2B
  • Septin-2
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