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抗Human NTRK3 抗体:
抗Rat (Rattus) NTRK3 抗体:
抗Mouse (Murine) NTRK3 抗体:
Human Polyclonal NTRK3 Primary Antibody for BR, CyTOF - ABIN5013014
Huang, Lai, Wu, Hsu, Cheng, Lan, Chiu: BDNF mediated TrkB activation is a survival signal for transitional cell carcinoma cells. in International journal of oncology 2010
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Human Polyclonal NTRK3 Primary Antibody for IHC (p), IHC - ABIN315971
Lawn, Krishna, Pisklakova, Qu, Fenstermacher, Fournier, Vrionis, Tran, Chan, Kenchappa, Forsyth: Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells. in The Journal of biological chemistry 2015
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Human Monoclonal NTRK3 Primary Antibody for ELISA, WB - ABIN969324
Hisaoka, Sheng, Tanaka, Hashimoto: Gene expression of TrkC (NTRK3) in human soft tissue tumours. in The Journal of pathology 2002
Human Polyclonal NTRK3 Primary Antibody for FACS - ABIN4897363
Rezaee, Rellick, Piedimonte, Akers, OLeary, Martin, Craig, Gibson: Neurotrophins regulate bone marrow stromal cell IL-6 expression through the MAPK pathway. in PLoS ONE 2010
Human Monoclonal NTRK3 Primary Antibody for CyTOF, FACS - ABIN4900210
Delcroix, Curtis, Schiller, Montero-Menei: EGF and bFGF pre-treatment enhances neural specification and the response to neuronal commitment of MIAMI cells. in Differentiation; research in biological diversity 2010
LINC00052 could regulate NTRK3 expression by forming complementary base pairing with miR (显示 MLXIP 抗体)-128 and miR (显示 MLXIP 抗体)-485-3p to reduce the luciferase activity of NTRK3 3'UTR (显示 UTS2R 抗体).
Case Reports: mammary analog secretory carcinoma of the thyroid gland with ETV6 (显示 ETV6 抗体) rearrangement and ETV6 (显示 ETV6 抗体)-NTRK3 gene fusion.
The prevalence of ETV6 (显示 ETV6 抗体)-NTRK3 kinase fusions were determined in papillary thyroid cancer of adult population
We report the case of a patient with an initial diagnosis of salivary acinic cell carcinoma later reclassified as Mammary analogue secretory carcinoma after next-generation sequencing revealed an ETV6-NTRK3 fusion.
Data suggest that kinase domains of neurotrophin (显示 BDNF 抗体) receptor isoforms, TRKA (显示 NTRK1 抗体), TRKB (显示 NTRK2 抗体), and TRKC, exhibit a bulky phenylalanine gatekeeper, leading to a small and unattractive back pocket/binding site for antineoplastic kinase inhibitors. [REVIEW]
Pan (显示 SUPT6H 抗体)-Trk (显示 NTRK1 抗体) immunohistochemistry is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma.
5 gastrointestinal stromal tumors cases lacking alterations in the KIT/PDGFRA (显示 PDGFRA 抗体)/SDHx/RAS pathways, including two additional cases with FGFR1 (显示 FGFR1 抗体)-TACC1 (显示 TACC1 抗体) and ETV6 (显示 ETV6 抗体)-NTRK3 fusions, are reported.
High expression of TrkC is associated with glioblastoma.
Study found that copy number variations of NTRK3 were associated with platinum-sensitive and platinum-resistant recurrences. Amplification of NTRK3 perfectly predicted platinum-sensitive relapse of ovarian cancer.
we demonstrate the expression of the ETV6-NTRK3 fusion oncogene (显示 RAB1A 抗体) in a small subset of inflammatory myofibroblastic tumors
our data suggest that Runx3 (显示 RUNX3 抗体) may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 variants
adult homozygous TrkAC knock-in mice displayed severe deficits in acute and tissue injury-induced pain, representing the first viable adult Trk (显示 NTRK1 抗体) mouse mutant with a pain phenotype
TrkC expression in E13.5 VCG neurons requires NeuroD (显示 NEUROD1 抗体) and that TrkC expression may be necessary for the normal migration and innervations of those neurons.
The dependence receptor TrkC interacts with Cobra1 (显示 COBRA1 抗体).TrkC killer fragment shuttles with Cobra1 (显示 COBRA1 抗体) to the mitochondria to engage apoptosis.
ETV6 (显示 ETV6 抗体)-SAM (显示 TTN 抗体) domain interface mutations block ETV6 (显示 ETV6 抗体)-NTRK3-induced cellular transformation
This study demonistrated that NTRK3 plays a role in panic disorder by regulating hippocampus-dependent fear memories.
Despite elimination of TrkC mRNA, no differences in development of kindling were detected between TrkC conditional null and wild type control mice.
find that both IRS1 (显示 IRS1 抗体) and kinase active IGF1R (显示 IGF1R 抗体) are required for ETV6 (显示 ETV6 抗体)-NTRK3 transformation, that tyrosine phosphorylated IRS1 (显示 IRS1 抗体) is present in high molecular weight complexes with EN and IGF1R (显示 IGF1R 抗体), and that EN colocalizes with IGF1R (显示 IGF1R 抗体) at the plasma membrane
Data describe the distribution and changes of TrkB (显示 NTRK2 抗体) and TrkC in the dopamine neurons of the substantia nigra by comparison of control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP (显示 PTPN2 抗体)) Parkinson disease mouse model.
Data suggest that postsynaptic TrkC trans interaction with presynaptic PTPsigma (显示 PTPRS 抗体) generates bidirectional adhesion and recruitment essential for excitatory synapse development and positions these signaling molecules at the center of synaptic pathways.
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
, ETV6-NTRK3 fusion
, NT-3 growth factor receptor
, tyrosine kinase receptor C
, neural receptor protein-tyrosine kinase (trkC)
, trkC tyrosine kinase
, neurotrophic tyrosine kinase receptor type 3
, tyrosine kinase C receptor, TrkC receptor, high-affinity neurotrophin receptor
, neurotrophic tyrosine kinase, receptor, type 3
, NT-3 growth factor receptor-like