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抗Human FLT4 抗体:
抗Mouse (Murine) FLT4 抗体:
抗Rat (Rattus) FLT4 抗体:
Mouse (Murine) Polyclonal FLT4 Primary Antibody for CyTOF, FACS - ABIN4899930
Benedito, Rocha, Woeste, Zamykal, Radtke, Casanovas, Duarte, Pytowski, Adams: Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. in Nature 2012
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Human Monoclonal FLT4 Primary Antibody for FACS - ABIN4896918
Roorda, Ter Elst, Scherpen, Meeuwsen-de Boer, Kamps, de Bont: VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms. in European journal of cancer (Oxford, England : 1990) 2010
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Human Monoclonal FLT4 Primary Antibody for FACS - ABIN4896919
Shawber, Funahashi, Francisco, Vorontchikhina, Kitamura, Stowell, Borisenko, Feirt, Podgrabinska, Shiraishi, Chawengsaksophak, Rossant, Accili, Skobe, Kitajewski: Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. in The Journal of clinical investigation 2007
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Human Monoclonal FLT4 Primary Antibody for ELISA (Detection), FACS - ABIN4899932
Mouawad, Spano, Comperat, Capron, Khayat: Tumoural expression and circulating level of VEGFR-3 (Flt-4) in metastatic melanoma patients: correlation with clinical parameters and outcome. in European journal of cancer (Oxford, England : 1990) 2009
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Human Monoclonal FLT4 Primary Antibody for WB - ABIN1882290
Pajusola, Aprelikova, Korhonen, Kaipainen, Pertovaara, Alitalo, Alitalo: FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. in Cancer research 1992
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Human Monoclonal FLT4 Primary Antibody for ELISA, WB - ABIN969147
Goodyear, Kheyfets, Garcia, Stearns: Role of the VEGFR3/VEGFD receptor axis in TGFbeta1 activation of primary prostate cell lines. in The Prostate 2009
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Human Polyclonal FLT4 Primary Antibody for FACS, IF (p) - ABIN678578
Wang, Zhou, Lin, Wang, Lin, Li: RhGH attenuates ischemia injury of intrahepatic bile ducts relating to liver transplantation. in The Journal of surgical research 2011
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Mouse (Murine) Monoclonal FLT4 Primary Antibody for IHC (fro), IHC (p) - ABIN967368
Kubo, Fujiwara, Jussila, Hashi, Ogawa, Shimizu, Awane, Sakai, Takabayashi, Alitalo, Yamaoka, Nishikawa: Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis. in Blood 2000
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Human Monoclonal FLT4 Primary Antibody for IHC, ELISA - ABIN1003451
Jussila, Valtola, Partanen, Salven, Heikkilä, Matikainen, Renkonen, Kaipainen, Detmar, Tschachler, Alitalo, Alitalo: Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3. in Cancer research 1998
Mouse (Murine) Monoclonal FLT4 Primary Antibody for WB - ABIN1589862
Tempfer, Kaser-Eichberger, Korntner, Lehner, Kunkel, Traweger, Trost, Strohmaier, Bogner, Runge, Bruckner, Krefft, Heindl, Reitsamer, Schrödl: Presence of lymphatics in a rat tendon lesion model. in Histochemistry and cell biology 2015
Lymphangiogenic growth in the diaphragm was highly dependent on vascular endothelial growth factor receptor (显示 RYK 抗体) (VEGFR)-3 signaling. During diaphragm development, macrophages appeared first in a linearly arranged pattern, followed by ingrowth of lymphatic vessels along these patterned lines.
found that WT1 (显示 WT1 抗体) and KDR (显示 KDR 抗体) are co-expressed in Sertoli cells of the testes and somatic cells of embryonic ovaries. Furthermore, WT1 (显示 WT1 抗体) bound to the Kdr (显示 KDR 抗体) promoter in the chromatin of embryonic testes and ovaries. KDR (显示 KDR 抗体) signaling represses the testis-promoting gene Sox9 (显示 SOX9 抗体) in embryonic XX gonads
This is the first report demonstrating the spatiotemporal expression patterns of Flk1 (显示 KDR 抗体) and Flt1 (显示 FLT1 抗体) in the coronary vascular system during development and after MI; thus, this study suggests that these factors have distinct and important functions in coronary angiogenesis.
VEGFR2 (显示 KDR 抗体)-associated alpha(2,6)-linked sialic acid plays an important role in modulating VEGF (显示 VEGFA 抗体)/VEGFR2 (显示 KDR 抗体) interaction, EC pro-angiogenic activation and neovessel formation.
These results revealed that vascular sprouting and permeability are both controlled through the VEGFR2-TSAd-c-Src signaling pathway in a subset of tissues, which may be useful in developing strategies to control tissue-specific pathological angiogenesis.
Data show that editing of genomic VEGFR2 (显示 KDR 抗体) locus using rAAV1-mediated CRISPR/Cas9 abrogates angiogenesis in the mouse models of oxygen-induced retinopathy and laser-induced choroid neovascularization.
Our study demonstrates that Prox1 (显示 C16orf35 抗体)-GFP/Flk1 (显示 KDR 抗体)::myr-mCherry mice are a useful model for studying coordinated hemangiogenic and lymphangiogenic responses
Endoglin (显示 ENG 抗体) prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 (显示 KDR 抗体) signalling
CLEC14A (显示 CLEC14A 抗体) acts in vascular homeostasis by fine-tuning VEGFR-2 (显示 KDR 抗体) and VEGFR-3 signaling in endothelial cells
The elevated soluble VEGFR-2 (显示 KDR 抗体) that was found in the aortas of apoE (显示 APOE 抗体)(-/-) mice with atherosclerosis binds to and diminishes the activity of VEGF-C (显示 VEGFC 抗体).
Rare inherited and de novo variants in 2,871 congenital heart disease probands identified GDF1 (显示 GDF1 抗体), MYH6 (显示 MYH6 抗体), and FLT4 as causative genes.
Data show that VEGF-C (显示 VEGFC 抗体), VEGF-D (显示 Figf 抗体), and VEGFR-3 were expressed in a substantial percentage of breast carcinomas.
There was a significant decrease in VEGFR3 expression in pulmonary arterial endothelial cells from pulmonary arterial hypertension patients.
By treating LECs with VEGF (显示 VEGFA 抗体)-C156S and analyzing subsequent changes in gene expression, we identified several 'immediate early (显示 JUN 抗体)' transcription factors that showed a rapid transient upregulation VEGFR-3 stimulation. these results reveal an important and unanticipated role of HOXD10 (显示 HOXD10 抗体) in the regulation of VEGFR-3 signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability.
The normalized methylation values for the VEGFR1 (显示 FLT1 抗体), VEGFR2 (显示 KDR 抗体) and VEGFR3 promoters tended to be higher in the tumour cell lines than in normal tonsil samples, whereas amounts of VEGFR1 (显示 FLT1 抗体), VEGFR2 (显示 KDR 抗体) and VEGFR3 messenger RNA were significantly higher
These results indicate that VEGF-C (显示 VEGFC 抗体)-induced MSC (显示 MSC 抗体) osteogenesis is mediated through VEGFR2 (显示 KDR 抗体) and VEGFR3, and followed the activation of the ERK (显示 EPHB2 抗体)/RUNX2 (显示 RUNX2 抗体) signaling pathway.
Assessment of VEGFR-2/VEGFR (显示 KDR 抗体)-3 on tumor samples might serve as a putative prognostic factor in renal cell carcinoma (显示 MOK 抗体) cases, identifying a subset of patients that may benefit from antiangiogenic treatments targeting VEGFR (显示 KDR 抗体) receptors.
This study suggests that NRP1 (显示 NELL1 抗体) expression and LVD are independent factors that are likely to predict the risk of LN metastasis in squamous cell carcinoma (SCC (显示 CYP11A1 抗体))of the tongue, whereas the expression of VEGFC (显示 VEGFC 抗体), VEGFR3, CCR7 (显示 CCR7 抗体), and SEMA3E (显示 SEMA3E 抗体) are nonindependent predictive factors
Data indicate that vascular endothelial growth factor D (VEGF-D (显示 Figf 抗体)) was the best indicator of metastasis and vascular endothelial growth factors and receptor-3 (VEGFR-3) may help to determine the prognosis and management of colorectal cancer (CRC (显示 CALR 抗体)).
The summarizes the structure and function features of pathway-related molecules of VEGFC (显示 VEGFC 抗体)/D-VEGFR3/NRP2 (显示 NELL2 抗体) axis, stages of various tumors and their molecular mechanisms and significances in tuthe expression changes of these molecules in different anatomic organs or histopathologic types or development lymphatic metastasis.
miR (显示 MYLIP 抗体)-126a directs lymphatic endothelial cell sprouting and extension by interacting with Cxcl12a-mediated chemokine (显示 CCL1 抗体) signaling and Vegfc (显示 VEGFC 抗体)-Flt4 signal axis.
Ca(2 (显示 CA2 抗体)+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal (显示 CARD8 抗体) vein, respectively.
Experiments in mice and zebrafish demonstrate that changing levels of VEGFR3/Flt4 modulates aortic lumen diameter consistent with flow-dependent remodeling
In the embryo, phenotypes driven by increased Vegfc (显示 VEGFC 抗体) are suppressed in the absence of Ccbe1 (显示 CCBE1 抗体), and Vegfc (显示 VEGFC 抗体)-driven sprouting is enhanced by local Ccbe1 (显示 CCBE1 抗体) overexpression. Moreover, Vegfc (显示 VEGFC 抗体)- and Vegfr3-dependent Erk (显示 MAPK1 抗体) signaling is impaired in the absence of Ccbe1 (显示 CCBE1 抗体).
Flt4 plays an essential role in lymphangiogenesis [review]
The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc (显示 VEGFC 抗体)/Vegfr3 signaling in zebrafish.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
flt4 signalling is suppressed by Dll4 (显示 DLL4 抗体) in developing zebrafish intersegmental arteries.
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.
, fms-like tyrosine kinase 4
, soluble VEGFR3 variant 1
, soluble VEGFR3 variant 2
, soluble VEGFR3 variant 3
, tyrosine-protein kinase receptor FLT4
, vascular endothelial growth factor receptor 3
, chylous ascites
, receptor protein tyrosine kinase
, vascular endothelial growth factor receptor-3
, FMS-like tyrosine kinase 4
, tyrosine kinase VEGFR-3
, receptor tyrosine kinase Flt4