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抗Human Epiregulin 抗体:
抗Mouse (Murine) Epiregulin 抗体:
抗Rat (Rattus) Epiregulin 抗体:
we showed that epidermal growth factor (显示 EGF 抗体) receptors (EGFR (显示 EGFR 抗体)) were constitutively activated in metastatic lung subtypes of salivary adenoid cystic carcinoma cells, and that this activation was induced by autocrine expression of epiregulin
Study shows how the EGFR (显示 EGFR 抗体) ligands epiregulin (EREG) and epigen (EPGN (显示 EPGN 抗体)) stabilize different dimeric conformations of the EGFR (显示 EGFR 抗体) extracellular region. Results reveal how responses to different EGFR (显示 EGFR 抗体) ligands are defined by receptor dimerization strength and signaling dynamics. These findings have broad implications for understanding receptor tyrosine kinase (显示 RET 抗体) (RTK) signaling specificity.
EREG and MMP-1 (显示 MMP1 抗体) were found to be elevated in nasal polyp and uncinate tissues in patients with Chronic rhinosinusitis with nasal polyps.
upregulation of EREG expression through promoter demethylation might be an important means of activating the EGFR (显示 EGFR 抗体) pathway during the genesis of colorectal adenocarcinoma (CRC (显示 CALR 抗体)) and potentially other cancers.
EREG and AREG (显示 AREG 抗体) are strongly regulated by methylation, and their expression is associated with CIMP status and primary tumour site.
three-dimensional structure of the EPR antibody (the 9E5(Fab (显示 FANCB 抗体)) fragment) in the presence and absence of EPR
Together, these studies lead to identification of a novel pathway involving EREG and MMP-1 (显示 MMP1 抗体) that contributes to the formation of early stage breast cancer
These results suggested that EREG is one of the molecules involved in glioma malignancy
Data indicate that the effects of epiregulin (EREG) and V-ATPase (显示 ATP6V1H 抗体) (TCIRG1 (显示 TCIRG1 抗体)) single nucleotide polymorphism (SNP) on pulmonary tuberculosis susceptibility, to the extent that they exist, are dependent on gene-gene interactions in West African populations.
Patients homozygous for the minor allele A of EREG rs12641042 had a significantly higher 3-year survival rate than patients with allele C (HR 0.48; P=0.034), but significance was lost in multivariable analysis
RHOA (显示 RHOA 抗体) loss reduces YAP (显示 YAP1 抗体) signaling of the Hippo pathway and affects YAP (显示 YAP1 抗体) effector epiregulin (EREG) expression in the crypts. Expression of an active YAP (显示 YAP1 抗体) (S112A) mutant rescues ntestinal stem cells (ISCs (显示 NFS1 抗体)) marker expression, ISC regeneration, and ISC-associated Wnt (显示 WNT2 抗体) signaling, but not defective epithelial polarity, in RhoA (显示 RHOA 抗体) knockout mice, implicating YAP (显示 YAP1 抗体) in RHOA (显示 RHOA 抗体)-regulated ISC function.
Collectively, these data indicate that Yap (显示 YAP1 抗体)-induced Epiregulin signaling promotes the identity of submandibular gland ductal progenitors and that removal of nuclear Yap (显示 YAP1 抗体) by Lats1 (显示 LATS1 抗体)/2-mediated signaling is critical for proper ductal maturation.
Epiregulin and EGFR (显示 EGFR 抗体) interactions have roles in pain processing
High expression of EREG is associated with lung carcinogenesis.
The lack of the growth factor Ereg results in significantly reduced lung tumor development in a primary chemically induced tumor promotion model compared to wildtype controls (Ereg+/+ mice).
Pre-maturation with cAMP modulators in conjunction with EGF (显示 EGF 抗体)-like peptides during in vitro maturation enhances mouse oocyte developmental competence.
Epiregulin promotes the proliferation of liver progenitor cells and DNA synthesis by hepatocytes and is upregulated in the serum of patients with liver injury.
EREG and tumor-associated fibroblasts play a crucial role in controlling tumor growth in colitis-associated neoplasms.
Epiregulin can effectively mature isolated cumulus-oocyte complexes, but fails as a substitute for the hCG (显示 CGA 抗体)/epidermal growth factor (显示 EGF 抗体) stimulus on cultured follicles.
Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors.