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抗Human EPGN 抗体:
抗Mouse (Murine) EPGN 抗体:
抗Rat (Rattus) EPGN 抗体:
Study shows how the EGFR (显示 EGFR 抗体) ligands epiregulin (EREG (显示 EREG 抗体)) and epigen (EPGN) stabilize different dimeric conformations of the EGFR (显示 EGFR 抗体) extracellular region. Results reveal how responses to different EGFR (显示 EGFR 抗体) ligands are defined by receptor dimerization strength and signaling dynamics. These findings have broad implications for understanding receptor tyrosine kinase (显示 RET 抗体) (RTK) signaling specificity.
EPG is an EGF (显示 EGF 抗体)-like growth factor and a low affinity ligand
activation of the EGFR (显示 EGFR 抗体) by its ligand epigen during early epidermal development causes hyperplasia of the sebaceous gland and, to a minor extent, hyperplasia of the interfollicular epidermis and increased hair follicles density.
Epigen has non-essential functions or functions that can be compensated by other EGFR (显示 EGFR 抗体) ligands during growth and tissue homeostasis.
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants.
, epithelial mitogen homolog