This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. [provided by RefSeq, Jul 2008].
Mihaylova, Cheng, Cao, Tripathi, Mana, Bauer-Rowe, Abu-Remaileh, Clavain, Erdemir, Lewis, Freinkman, Dickey, La Spada, Huang, Bell, Deshpande, Carmeliet, Katajisto, Sabatini, Yilmaz: "Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging." in: Cell stem cell, Vol. 22, Issue 5, pp. 769-778.e4, (2019) (PubMed).
Park, Choi, Kim, Cheong, Jeong: "AhR activation by 6-formylindolo[3,2-b]carbazole and 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibit the development of mouse intestinal epithelial cells." in: Environmental toxicology and pharmacology, Vol. 43, pp. 44-53, (2017) (PubMed).
Du, Luo, Li, Tan, Han, Lu, Li, Qian, Zhang, Zhao, Liu: "Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression." in: The Journal of biological chemistry, Vol. 288, Issue 21, pp. 15131-41, (2013) (PubMed).
Das, Png, Oancea, Hasnain, Lourie, Proctor, Eri, Sheng, Crane, Florin, McGuckin: "Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins." in: The Journal of experimental medicine, Vol. 210, Issue 6, pp. 1201-16, (2013) (PubMed).