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RSPO1 产品

(R-Spondin 1 (RSPO1))
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. [provided by RefSeq, Jul 2008].

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Featured RSPO1 Categories

RSPO1 抗体

High quality antibodies with extensive validation data.

RSPO1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

RSPO1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended RSPO1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (8)
Cat. No. ABIN7430144
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7430147
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (8)
Cat. No. ABIN7437200
Quantity 100 μL
Datasheet Datasheet

Recommended RSPO1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6959020
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6975875
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6999503
Quantity 96 tests
Datasheet Datasheet

Recommended RSPO1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source CHO Cells
Validations
  • (3)
Cat. No. ABIN7275537
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
  • (3)
Cat. No. ABIN2181684
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275538
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our RSPO1 Products

Igarashi, Miura, Williams, Jaksch, Kadowaki, Yamauchi, Guarente: "NAD+ supplementation rejuvenates aged gut adult stem cells." in: Aging cell, Vol. 18, Issue 3, pp. e12935, (2020) (PubMed).

Mihaylova, Cheng, Cao, Tripathi, Mana, Bauer-Rowe, Abu-Remaileh, Clavain, Erdemir, Lewis, Freinkman, Dickey, La Spada, Huang, Bell, Deshpande, Carmeliet, Katajisto, Sabatini, Yilmaz: "Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging." in: Cell stem cell, Vol. 22, Issue 5, pp. 769-778.e4, (2019) (PubMed).

Park, Choi, Kim, Cheong, Jeong: "AhR activation by 6-formylindolo[3,2-b]carbazole and 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibit the development of mouse intestinal epithelial cells." in: Environmental toxicology and pharmacology, Vol. 43, pp. 44-53, (2017) (PubMed).

Choi, Chang, Cho, Kang, Shin, Song, Lee et al.: "The association of radiographic progression with serum R-spondin 1 (RSPO1) levels or Dickkopf-1 (DKK1)/RSPO1 ratios in rheumatoid arthritis patients: clinical evidence for reciprocal inhibition ..." in: Scandinavian journal of rheumatology, Vol. 43, Issue 6, pp. 453-61, (2014) (PubMed).

Du, Luo, Li, Tan, Han, Lu, Li, Qian, Zhang, Zhao, Liu: "Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression." in: The Journal of biological chemistry, Vol. 288, Issue 21, pp. 15131-41, (2013) (PubMed).

Moad, Pioszak: "Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli." in: Biochemistry, Vol. 52, Issue 41, pp. 7295-304, (2013) (PubMed).

Das, Png, Oancea, Hasnain, Lourie, Proctor, Eri, Sheng, Crane, Florin, McGuckin: "Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins." in: The Journal of experimental medicine, Vol. 210, Issue 6, pp. 1201-16, (2013) (PubMed).

Tomaselli, Megiorni, De Bernardo, Felici, Marrocco, Maggiulli, Grammatico, Remotti, Saccucci, Valentini, Mazzilli, Majore, Grammatico: "Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." in: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).

Parma, Radi, Vidal, Chaboissier, Dellambra, Valentini, Guerra, Schedl, Camerino: "R-spondin1 is essential in sex determination, skin differentiation and malignancy." in: Nature genetics, Vol. 38, Issue 11, pp. 1304-9, (2006) (PubMed).

Takahashi, Sato, Kurashima, Yamamoto, Kurokawa, Yuki, Takemura, Uematsu, Lai, Otsu, Matsuno, Osawa, Mizushima, Nishimura, Hayashi, Yamaguchi, Kiyono: "A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids." in: Stem cell reports, Vol. 10, Issue 1, pp. 314-328 (PubMed).

Synonyms and alternative names related to RSPO1

R-spondin 1 (Rspo1), R-spondin 1 (RSPO1), R-spondin 1 (LOC100049655), R-spondin 1 (rspo1), CRISTIN3, R-spondin, RGD1565558, RSPO, Rspondin, wu:fj81e05, zgc:92153

Protein level used designations for RSPO1

  • R-spondin-1
  • R-spondin homolog
  • roof plate-specific spondin-1
  • R-spondin1
  • cristin-3
  • cysteine-rich and single thrombospondin domain-containing protein 3
  • mCristin-3
  • thrombospondin type 1 domain containing gene Rspondin
  • ovarian R-spondin member 1
  • Roof plate-specific spondin-1
  • cb1071
  • fj81e05
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