RRM2B 抗体
(Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010].
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49 results
RRM2B
适用: 大鼠
WB, IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 350
RRM2B
适用: 人, 大鼠, 小鼠, 猴, Cow, 兔, 马, Pig, Bat, 非洲爪蟾, 小鸡, 绵羊
WB
宿主: 兔
Polyclonal
unconjugated
RRM2B
适用: 人, 大鼠, 小鼠, Cow, 兔, 马, Pig, 犬, 豚鼠, Saccharomyces cerevisiae, 斑马鱼
WB
宿主: 兔
Polyclonal
unconjugated
1 image
Latest Publications for our RRM2B 抗体
: "Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer." in: American journal of translational research, Vol. 10, Issue 11, pp. 3635-3649, (2018) (PubMed).: "p53R2 regulates thioredoxin reductase activity through interaction with TrxR2." in: Biochemical and biophysical research communications, Vol. 482, Issue 4, pp. 706-712, (2016) (PubMed).
: "Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells." in: Oncotarget, Vol. 7, Issue 2, pp. 1984-99, (2016) (PubMed).
: "RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence." in: Scientific reports, Vol. 2, pp. 822, (2013) (PubMed).
: "Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer." in: Cancer research, Vol. 71, Issue 9, pp. 3202-13, (2011) (PubMed).
: "Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells." in: Biochemical and biophysical research communications, Vol. 410, Issue 1, pp. 102-7, (2011) (PubMed).
: "Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2." in: Oncogene, Vol. 28, Issue 21, pp. 2173-84, (2009) (PubMed).
: "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits." in: Cancer research, Vol. 63, Issue 5, pp. 980-6, (2003) (PubMed).
: "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40647-51, (2001) (PubMed).
: "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint." in: Cancer research, Vol. 61, Issue 22, pp. 8256-62, (2001) (PubMed).
Aliases for RRM2B 抗体
ribonucleotide reductase M2 B (TP53 inducible) S homeolog (rrm2b.S) 抗体ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B) 抗体
ribonucleotide reductase M2 B (TP53 inducible) (rrm2b) 抗体
ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b) 抗体
ribonucleotide reductase regulatory TP53 inducible subunit M2B (Rrm2b) 抗体
MTDPS8A 抗体
MTDPS8B 抗体
p53r2 抗体
P53R2 抗体
p53R2 抗体
RRM2B 抗体
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