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Human Polyclonal NCBP1 Primary Antibody for WB - ABIN1881565
Hwang, Sato, Tang, Matsuda, Maquat: UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps. in Molecular cell 2010
Show all 5 Pubmed References
Data show that Cbp80 knockdown not only led to the upregulation of transposons, but also to delocalization of Piwi (显示 PIWIL1 抗体), Aub and Ago3 (显示 EIF2C3 抗体), key factors in the piRNA biosynthesis pathway.
Sgf11 interacts with the cap-binding protein 80 (Cbp80) component of the cap-binding complex, and that Cbp80 knockdown interferes with Sgf11 recruitment on the hsp70 promoter.
Study proposes the existence of an alternative cap-binding complex involving NCBP1 and NCBP3 that plays a key role in mRNA biogenesis.
down-regulation of CTIF (显示 KIAA0427 抗体) using a small interfering RNA causes a redistribution of CBP80 from polysome fractions to subpolysome fractions, without significant consequence to eIF4E (显示 EIF4E 抗体) distribution
Cellular processes by which CBP80-CBP20 (显示 NCBP2 抗体) -bound messenger ribonucleoproteins (mRNPs) are remodeled to eIF4E (显示 EIF4E 抗体)-bound mRNPs, are overviewed.
Viral mRNA associates with the influenza virus A NS1 (显示 PTPN11 抗体) and the cellular NCBP1 of the nuclear cap-binding complex.
UPF1 (显示 UPF1 抗体) binds PTC (显示 F9 抗体)-containing mRNA more efficiently than the corresponding PTC (显示 F9 抗体)-free mRNA in a way that is promoted by the UPF1 (显示 UPF1 抗体)-CBP80 interaction.
crystal structure at 2.1 A resolution of CBP20 (显示 NCBP2 抗体) and CBP80 bound to an m(7)GpppG cap analogue
Structural basis of m7GpppG binding to the nuclear cap-binding protein (显示 EIF4E 抗体) complex.
The organization of the CBP80-CBP20 (显示 NCBP2 抗体) complex suggests how the activity of eIF4G (显示 EIF4G1 抗体) in translation initiation could be regulated through a dynamic network of overlapping intra- and intermolecular interactions.
During nonsense-mediated mRNA decay, CBP80 interacts with Upf1 (显示 UPF1 抗体) and promotes the interaction of Upf1 (显示 UPF1 抗体) with Upf2 (显示 UPF2 抗体) but not with Stau1 (显示 STAU1 抗体).
Association of CBC with PARN (显示 PARN 抗体) might have importance in the regulated recruitment of PARN (显示 PARN 抗体) to the nonsense-mediated decay pathway during the pioneer round of translation.
the identification of new genes involved in ABA-dependent abiotic stresses using Arabidopsis suppressor mutants of abh1 (显示 ALKBH 抗体) hypersensitivity to ABA during seed germination.
Data suggest that CBP20 (显示 NCBP2 抗体) and CBP80 (ABH1) have synergistic roles during the salt stress response.
SERRATE, CAP BINDING PROTEIN20 (CBP20 (显示 NCBP2 抗体)), and CBP80 are regulators of lincRNA expression and biogenesis. RT-PCR experiments confirmed these three proteins are also needed for splicing of a small group of intron-containing lincRNAs.
This intron suppression of transgene silencing requires efficient intron splicing and is dependent on ABH1 (显示 ALKBH 抗体).
ABH1 (CBP80) encodes a large subunit of CBC (CAP BINDING COMPLEX) and the abh1 (显示 ALKBH 抗体) mutant is drought-tolerant and hypersensitive to ABA during seed germination.
The cbp80(abh1) and cbp20 (显示 NCBP2 抗体)/80 mutants had many more changes in alternative splicing in common than did cbp20 (显示 NCBP2 抗体) and cbp20 (显示 NCBP2 抗体)/80 suggesting that CBP80 plays a more significant role in alternative splicing than CBP20 (显示 NCBP2 抗体).
Abh1 (显示 ALKBH 抗体) lesion affects several developmental processes, perhaps because the processing of certain mRNAs.
CBP20 and CBP80 function in miRNA biogenesis by binding to pri-miRNA transcripts, and are stabilized by ABA by a post-translational mechanism.
AtCBP80 is required for the stability of AtCBP20 (显示 NCBP2 抗体) in the plant cell.
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay.
, Cap-binding protein 80
, nuclear cap-binding protein subunit 1
, NCBP 80 kDa subunit
, 80 kDa nuclear cap-binding protein
, nuclear cap-binding protein subunit 1-B
, nuclear cap binding protein subunit 1, 80kDa
, nuclear cap-binding protein subunit 1-like
, nuclear cap-binding protein subunit 1-A