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Human Polyclonal EIF5A Primary Antibody for ELISA, WB - ABIN4307667
Koettnitz, Kappel, Baumruker, Hauber, Bevec: The genomic structure encoding human initiation factor eIF-5A. in Gene 1994
EIF5A1 is a vital regulator of epithelial ovarian cancer proliferation and progression.
Molecular structure of the exportin (显示 XPO1 抗体) Xpo4 (显示 XPO4 抗体) in complex with RanGTP and the hypusine-containing translation factor eIF5A (显示 EIF5 抗体) has been reported.
the depletion of eIF5A (显示 EIF5 抗体) leads to endoplasmic reticulum stress, an unfolded protein response and up-regulation of chaperone expression in HeLa cells.
Findings indicate that eIF5A (显示 EIF5 抗体)-PEAK1 (显示 PEAK1 抗体)-YAP (显示 YAP1 抗体) signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity.
eIF5A1 isoform A has a role in mitochondrial function.
These results suggest that binding of eEF2 (显示 EEF2 抗体) to the ribosome alters its conformation, resulting in a weakened affinity of eIF5A (显示 EIF5 抗体) and impairment of this interplay compromises cell growth due to translation elongation defects.
eIF5A (显示 EIF5 抗体)-2 protein was highly expressed in gastric cancer tissues
Upregulation of translation initiation factor 5a observed in thalassemia is a novel finding and plays a protective role toward cell survival under oxidative stress.
Our results suggest that functional, hypusinated eIF5A (显示 EIF5 抗体) is necessary for HIF-1alpha (显示 HIF1A 抗体) expression during hypoxia and that eIF5A (显示 EIF5 抗体) is an attractive target for cancer therapy.
findings also implicate the eIF5A (显示 EIF5 抗体)/RhoA (显示 RHOA 抗体)/ROCK module as a potential new therapeutic target to treat metastatic PDAC cells
our results provide the first genetic evidence that the hypusine modification in eIF-5A is crucial for homeostasis in mammals
knockout of either the eIF5A-1 gene (Eif5a) or of the deoxyhypusine synthase (显示 DHPS 抗体) gene (Dhps (显示 DHPS 抗体)) caused early embryonic lethality in mice, indicating the essential nature of both eIF5A-1 and deoxyhypusine synthase (显示 DHPS 抗体) in mammalian development
These results point to a new functional role for eIF5A, relating it to embryogenesis, development, and cell differentiation.
a decrease in either active eIF5A or polyamines inhibits cell growth, indicating that eIF5A and polyamines are independently involved in cell growth
Results indicate that the N-terminal extension of the eukaryotic eIF5A contributes in signaling this protein to nuclear localization, despite of bearing no structural similarity with classical nuclear localization signals.
Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys (显示 LYZ 抗体) 50. Mouse EIF5A1 and EIF5A2 (显示 EIF5A2 抗体) encode two isoforms: eIF5AI and eIF5AII (显示 EIF5A2 抗体).
The deduced bovine eIF5A protein is 100% identical to human Eif5A.
phosphorylation of Ser(2) plays a role in regulation of nucleocytoplasmic shuttling of eIF5A in plant cells
Results describe the identification and characterization of nero, the Drosophila melanogaster deoxyhypusine hydroxylase (DOHH) homologue, and indicate that nero and eIF5A are required for cell growth and affect autophagy and protein synthesis.
This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19.
, eukaryotic initiation factor 5A
, eukaryotic translation initiation factor 5A-1
, rev-binding factor
, eukaryotic translation initiation factor 5A
, translation initiation factor 5A
, eukaryotic translation initiation factor 5a
, initiation factor 5a
, putative eukaryotic initiation factor 5a
, eukaryotic translation factor 5A
, eukaryotic initiatin factor 5A (3)
, eukaryotic translation initiation factor 5A L homeolog
, translation initiation factor eIF-5A