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抗Rat (Rattus) 抗体:
抗Mouse (Murine) 抗体:
Cow (Bovine) Polyclonal CDON Primary Antibody for ELISA, ICC - ABIN4297093
Kang, Feinleib, Knox, Ketteringham, Krauss: Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2003
Cdon is required to localize N-cadherin (显示 CDH2 抗体) to the cell membrane in migratory neural crest cells for directed migration.
In the developing optic vesicle, Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hedgehog (显示 SHH 抗体) protein, thereby limiting its dispersion.
We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis
CDO (显示 CDO1 抗体) is required for proliferation and survival of lung cancer cells via Hh signaling.
These data support the view that cell-adhesion molecule (显示 MCAM 抗体)-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs.
Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer.
Mutations in the CDON cause holoprosencephaly. (Review)
We found that CDON is overexpressed in prostate cancer
CDON must associate with both ligand and other hedgehog (显示 SHH 抗体)-receptor components, particularly PTCH1 (显示 PTCH1 抗体), for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly.
Hedgehog (显示 SHH 抗体) proteins interact with cell adhesion molecule (显示 MCAM 抗体), down-regulated by oncogenes (CDO (显示 CDO1 抗体)) and brother of CDO (BOC (显示 BOC 抗体)) in a conserved manner
CDO (显示 CDO1 抗体) and BOC (显示 BOC 抗体) play a role in differentiation of cells in the skeletal muscle lineage
CDO (显示 CDO1 抗体) and BOC (显示 BOC 抗体) forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact.
These results support a model whereby mutations in Cdon and prenatal ethanol exposure increase Septo-optic dysplasia risk through spatiotemporal perturbations in Shh (显示 SHH 抗体) signaling activity.
Mutation in the Cdon gene is associated with congenital nevus development.
Study assessed the role of the Shh (显示 SHH 抗体) receptor Cdon in the development of ventral tegmental area and substantia nigra pars (显示 EPRS 抗体) compacta dopamine neurons. Results suggest that Cdon plays an important role in the encoding of diversity within the population of dopamine neurons of the midbrain, influencing both the development of the mesocortical dopamine pathway as well as behavioral outputs that involve this neural circuitry.
Results suggest that a promyogenic cell adhesion molecule (显示 MCAM 抗体) Cdo (显示 CDO1 抗体) signaling is critical for Inward rectifier potassium channel Kir2.1 (显示 KCNJ2 抗体) activities in the induction of myogenic differentiation.
PKN2 (显示 PKN2 抗体) formed complexes with Cdo (显示 CDO1 抗体), APPL1 (显示 APPL1 抗体) and AKT (显示 AKT1 抗体) via its C-terminal region and this interaction appeared to be important for induction of AKT (显示 AKT1 抗体) activity as well as myoblast differentiation.
that Cdon participates in oligodendrocyte differentiation and myelination, most likely in the initial stages of development
Suggest that Cdo (显示 CDO1 抗体) is required for the full Shh (显示 SHH 抗体) signaling activation to induce efficient dopaminergic neuron neurogenesis.
Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1 (显示 PTCH1 抗体).
Cx43 (显示 GJA1 抗体) physically interacts with Cdo (显示 CDO1 抗体) to form dynamic complexes during myoblast differentiation
Stim1 (显示 STIM1 抗体) protein levels were decreased in Cdo (显示 CDO1 抗体)-deficient perinatal hindlimb muscles or primary myoblasts; this correlates with defective NFATc3 (显示 NFATC3 抗体) activation in Cdo (显示 CDO1 抗体)(-/-) myoblasts upon differentiation.
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis.
Cdon homolog (mouse)
, surface glycoprotein, Ig superfamily member
, cell adhesion molecule-related/down-regulated by oncogenes
, Cdon homolog
, immunoglobulin superfamily member
, CAM-related/down-regulated by oncogenes
, immunoglobulin superfamily member CDO
, oncogene-regulated cell adhesion molecule
, cysteine dioxygenase type 1
, cysteine dioxygenase type I