(PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))
This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq, Jul 2008].
Wang, Takenaka, Takeda: "PTIP promotes DNA double-strand break repair through homologous recombination." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 15, Issue 3, pp. 243-54, (2014) (PubMed).
Mu, Wang, Schimenti: "An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development." in: Molecular and cellular biology, Vol. 28, Issue 20, pp. 6439-51, (2008) (PubMed).