This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
da Silva Xavier, Rutter, Rutter: "Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 22, pp. 8319-24, (2004) (PubMed).
Rutter, Michnoff, Harper, Gardner, McKnight: "PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 8991-6, (2001) (PubMed).
Hofer, Spielmann, Stengel, Stier, Katschinski, Desbaillets, Gassmann, Wenger: "Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors." in: Biochemical and biophysical research communications, Vol. 288, Issue 4, pp. 757-64, (2001) (PubMed).
Guilhot, Benchaibi, Flechon, Samarut: "The 12S adenoviral E1A protein immortalizes avian cells and interacts with the avian RB product." in: Oncogene, Vol. 8, Issue 3, pp. 619-24, (1993) (PubMed).
Hu, Bautista, Edwards, Defeo-Jones, Jones, Harlow: "Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides." in: Molecular and cellular biology, Vol. 11, Issue 11, pp. 5792-9, (1991) (PubMed).
Aliases for PASK 抗体
PAS domain containing serine/threonine kinase (Pask) 抗体 PAS domain containing serine/threonine kinase (pask) 抗体 PAS domain containing serine/threonine kinase (PASK) 抗体 mKIAA0135 抗体 pas 抗体 PASK 抗体 PASKIN 抗体 STK37 抗体 wu:fb69h07 抗体