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USP33 was downregulated in gastric adenocarcinoma.
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Fluorescence-activated cell sorting experiment found no significant effect of USP33 on cell cycle, whereas the apoptotic caspase proteins were activated by USP33-overexpression and the interaction between USP33 and Robo1 protein was identified, and knockdown of Robo1 enhancing the oncogenic effect upon USP33-knockdown, suggesting that USP33 may inhibit tumor progression through Robo1 signaling.
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USP33 may indirectly regulate the degradation and recycling of CXCR4 through deubiquitinating beta-arrestin2, promoting colorectal tumor cell metastasis.
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the E3 ligase beta-TrCP regulates cellular USP33 levels by the ubiquitin-proteasomal proteolysis.
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Data show thata combining cyclin-dependent kinase 2 (CDK2) antagonism and ubiquitin thioesterase 33 (USP33) depletion augments anaphase catastrophe via changes in centrosomal protein of 110 kDa (CP110) protein expression.
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Data show that ubiquitin specific peptidase 33 (USP33) mediates nerve tissue proteins Slit-Robo signaling in lung cancer cell migration.
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USP33 as a previously unknown tumor-suppressing gene.
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Knockdown or chemical inhibition of p97 causes robust accumulation of USP33 due to inhibition of its degradation
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nutrient starvation induces RALB deubiquitylation by accumulation and relocalization of the deubiquitylase USP33 to RALB-positive vesicles
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using human cells, identification of a new mechanism for the regulation of centrosome duplication that requires USP33, a deubiquitinating enzyme that is able to regulate CP110 levels
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VDU1 has a role in amplifying the increase in type 2 iodothyronine deiodinase activity that results from catecholamine-stimulated de novo synthesis
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The solution structure of the ZnF UBP domain of USP33 has been determined.
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VDU1 was identified as a protein partner of hSP56.
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USP33 and Mdm2 function reciprocally and favor respectively the stability or lability of the receptor beta-arrestin complex
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USPs 20 and 33 serve as novel regulators that dictate both post-endocytic sorting as well as the intensity and extent of beta(2)AR signalling from the cell surface.
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Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling
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Data uncover a previously unknown function of USP33 and reveal a new player in Slit-Robo signaling in cancer cell migration.
