(Protein tyrosine Phosphatase, Receptor Type, G (PTPRG))
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008].
Nikolaienko, Hammel, Dubreuil, Zalmai, Hall, Mehzabeen, Karuppan, Harroch, Stella, Bouyain: "Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues." in: The Journal of biological chemistry, Vol. 291, Issue 41, pp. 21335-21349, (2016) (PubMed).
Liu, Kulp, Sugimoto, Jiang, Chang, Lin: "Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents." in: Breast cancer research and treatment, Vol. 71, Issue 1, pp. 21-35, (2002) (PubMed).
Aliases for PTPRG 抗体
protein tyrosine phosphatase, receptor type G (PTPRG) 抗体 protein tyrosine phosphatase, receptor type, G (Ptprg) 抗体 5430405N12Rik 抗体 AW046354 抗体 AW549872 抗体 HPTPG 抗体 PTPG 抗体 Ptpg 抗体 R-PTP-GAMMA 抗体 RPTPG 抗体 RPTPgamma 抗体