PTPN13 产品
(Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008].
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Recommended PTPN13 抗体
Product
Reactivity
Application
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Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7174093
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC (p), ICC, IHC (fro)
Validations
- (2)
Cat. No.
ABIN7444964
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
IHC, WB, IP, ICC
Validations
- (2)
Cat. No.
ABIN7444967
Quantity
100 μL
Datasheet
Datasheet
Recommended PTPN13 蛋白
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Reactivity
Source
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Quantity
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Reactivity
Human
Source
Escherichia coli (E. coli)
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Cat. No.
ABIN7419421
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7419424
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7419427
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PTPN13 Products
: "Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95." in: Nature communications, Vol. 10, Issue 1, pp. 3105, (2019) (PubMed).: "Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway." in: International journal of molecular sciences, Vol. 18, Issue 7, (2017) (PubMed).
: "Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability." in: Nature communications, Vol. 7, pp. 11853, (2016) (PubMed).
: "Proteins interacting with cloning scars: a source of false positive protein-protein interactions." in: Scientific reports, Vol. 5, pp. 8530, (2015) (PubMed).
: "PTPL1 and PKCδ contribute to proapoptotic signalling in prostate cancer cells." in: Cell death & disease, Vol. 4, pp. e576, (2013) (PubMed).
: "FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface." in: Molecular and cellular biology, Vol. 23, Issue 10, pp. 3623-35, (2003) (PubMed).
: "Structure determination and ligand interactions of the PDZ2b domain of PTP-Bas (hPTP1E): splicing-induced modulation of ligand specificity." in: Journal of molecular biology, Vol. 334, Issue 1, pp. 143-55, (2003) (PubMed).
: "Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells." in: The Journal of biological chemistry, Vol. 277, Issue 49, pp. 47861-9, (2002) (PubMed).
: "Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer." in: The American journal of pathology, Vol. 158, Issue 4, pp. 1335-44, (2001) (PubMed).
Synonyms and alternative names related to PTPN13
protein tyrosine phosphatase, non-receptor type 13 (PTPN13), tyrosine-protein phosphatase non-receptor type 13 (LOC100540743), protein tyrosine phosphatase, non-receptor type 13 (ptpn13), protein tyrosine phosphatase, non-receptor type 13 (Ptpn13), AI324989, FAP-1, hPTP1E, PNP1, ptp, PTP-BAS, PTP-BL, Ptp-bl, PTP1E, PTPL1, PTPLE, PTPN13, Ptpri, RIP, wu:fb50g04, zgc:162319Protein level used designations for PTPN13
- fas-associated protein-tyrosine phosphatase 1
- hPTPE1
- protein-tyrosine phosphatase 1E
- protein-tyrosine phosphatase PTPL1
- tyrosine-protein phosphatase non-receptor type 13
- protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
- protein tyrosine phosphatase, non-receptor type 13
- tyrosine-protein phosphatase non-receptor type 13-like
- PTP36
- protein tyrosine phosphatase DPZPTP
- protein tyrosine phosphatase PTP-BL
- protein-tyrosine phosphatase RIP
- tyrosine phosphatase
- protein Tyr phosphatase
- protein-tyrosine phosphatase BAS
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