PTPN11 抗体
(Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| PTPN11 抗体 | 人, 小鼠, 大鼠, 猴, Cow, 兔, 小鸡, 马, Pig, 非洲爪蟾, 斑马鱼 | 兔 Polyclonal |
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| PTPN11 抗体 (pTyr580) | 人, 小鼠, 大鼠, 猴, Cow, 兔, 小鸡, 马, Pig, 非洲爪蟾, 斑马鱼 | 兔 Polyclonal |
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| PTPN11 抗体 (pTyr542) | 人, 小鼠, 大鼠, 猴, Cow, 兔, 犬, 小鸡, 马, Pig, 非洲爪蟾 | 兔 Polyclonal |
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| PTPN11 抗体 (Biotin) | 人 | 小鼠 Monoclonal |
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| PTPN11 抗体 (PE) | 人 | 兔 Polyclonal |
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| PTPN11 抗体 (PE) | 人 | 小鼠 Monoclonal |
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| PTPN11 抗体 (FITC) | 人 | 兔 Polyclonal |
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| PTPN11 抗体 (FITC) | 人 | 小鼠 Monoclonal |
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| PTPN11 抗体 (HRP) | 人 | 小鼠 Monoclonal |
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| PTPN11 抗体 (HRP) | 人 | 兔 Polyclonal |
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| PTPN11 抗体 (AA 520-547) | 人, 小鼠 | 兔 Polyclonal |
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| PTPN11 抗体 (pSer576) | 人 | 兔 Polyclonal |
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| PTPN11 抗体 (pTyr542) | 人 | 兔 Polyclonal |
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| PTPN11 抗体 (C-Term) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| PTPN11 抗体 (N-Term) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| PTPN11 抗体 (pTyr580, pTyr584) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| PTPN11 抗体 (AA 246-520) (FITC) | 人 | 兔 Polyclonal |
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| PTPN11 抗体 (AA 246-520) (HRP) | 人 | 兔 Polyclonal |
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| PTPN11 抗体 (AA 246-520) (Biotin) | 人 | 兔 Polyclonal |
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| PTPN11 抗体 (AA 246-520) | 人 | 兔 Polyclonal |
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Primary Antibody
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠, 猴, Cow, 兔, 小鸡, 马, Pig, 非洲爪蟾, 斑马鱼
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- pTyr580
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠, 猴, Cow, 兔, 犬, 小鸡, 马, Pig, 非洲爪蟾
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- pTyr542
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 246CT9-8-2
- 标记
- Biotin
- 抗体亚型
- IgG1 kappa
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- PE
- 抗体亚型
- IgG
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 246CT9-8-2
- 标记
- PE
- 抗体亚型
- IgG1 kappa
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- FITC
- 抗体亚型
- IgG
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 246CT9-8-2
- 标记
- FITC
- 抗体亚型
- IgG1 kappa
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 246CT9-8-2
- 标记
- HRP
- 抗体亚型
- IgG1 kappa
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- HRP
- 抗体亚型
- IgG
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- FACS (Flow Cytometry: 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 520-547
Primary Antibody
- WB (Western Blotting: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- pSer576
Primary Antibody
- WB (Western Blotting: 所列应用)
- IP (Immunoprecipitation: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- pTyr542
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 510-560, C-Term
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IF (Immunofluorescence: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- IF (Immunofluorescence: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- pTyr580, pTyr584
Primary Antibody
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- FITC
- 抗体亚型
- IgG
- 抗原表位
- AA 246-520
Primary Antibody
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- HRP
- 抗体亚型
- IgG
- 抗原表位
- AA 246-520
Primary Antibody
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Biotin
- 抗体亚型
- IgG
- 抗原表位
- AA 246-520
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 246-520
Latest Publications for our PTPN11 抗体
: "Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis." in: Molecular immunology, Vol. 91, pp. 134-144, (2017) (PubMed).
: "Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells." in: Journal of Cancer, Vol. 6, Issue 2, pp. 151-9, (2015) (PubMed).
: "Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma." in: Gut, Vol. 63, Issue 9, pp. 1457-67, (2014) (PubMed).
: "Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma." in: Molecular & cellular proteomics : MCP, Vol. 12, Issue 5, pp. 1335-49, (2013) (PubMed).
: "A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells." in: Blood, Vol. 118, Issue 6, pp. 1504-15, (2011) (PubMed).
: "Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis." in: Cancer cell, Vol. 19, Issue 5, pp. 629-39, (2011) (PubMed).
: "Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway." in: Journal of cellular biochemistry, Vol. 112, Issue 10, pp. 2837-49, (2011) (PubMed).
: "Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells." in: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8003-12, (2010) (PubMed).
: "Mitochondrial DNA haplogroup 'R' is associated with Noonan syndrome of south India." in: Mitochondrion, Vol. 10, Issue 2, pp. 166-73, (2010) (PubMed).
: "The phosphatase Shp2 is required for signaling by the Kaposi's sarcoma-associated herpesvirus viral GPCR in primary endothelial cells." in: Virology, Vol. 397, Issue 2, pp. 379-88, (2010) (PubMed).
: "Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells." in: Journal of Cancer, Vol. 6, Issue 2, pp. 151-9, (2015) (PubMed).
: "Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma." in: Gut, Vol. 63, Issue 9, pp. 1457-67, (2014) (PubMed).
: "Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma." in: Molecular & cellular proteomics : MCP, Vol. 12, Issue 5, pp. 1335-49, (2013) (PubMed).
: "A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells." in: Blood, Vol. 118, Issue 6, pp. 1504-15, (2011) (PubMed).
: "Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis." in: Cancer cell, Vol. 19, Issue 5, pp. 629-39, (2011) (PubMed).
: "Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway." in: Journal of cellular biochemistry, Vol. 112, Issue 10, pp. 2837-49, (2011) (PubMed).
: "Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells." in: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8003-12, (2010) (PubMed).
: "Mitochondrial DNA haplogroup 'R' is associated with Noonan syndrome of south India." in: Mitochondrion, Vol. 10, Issue 2, pp. 166-73, (2010) (PubMed).
: "The phosphatase Shp2 is required for signaling by the Kaposi's sarcoma-associated herpesvirus viral GPCR in primary endothelial cells." in: Virology, Vol. 397, Issue 2, pp. 379-88, (2010) (PubMed).
Aliases for PTPN11 抗体
protein tyrosine phosphatase, non-receptor type 11 (PTPN11) 抗体protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) 抗体
protein tyrosine phosphatase, non-receptor type 11 S homeolog (ptpn11.S) 抗体
protein tyrosine phosphatase, non-receptor type 11, a (ptpn11a) 抗体
protein tyrosine phosphatase, non-receptor type 11, b (ptpn11b) 抗体
2700084A17Rik 抗体
AW536184 抗体
BPTP3 抗体
bptp3 抗体
CFC 抗体
cfc 抗体
fa14b09 抗体
NS1 抗体
ns1 抗体
PTP-1D 抗体
ptp-2 抗体
PTP1D 抗体
PTP2C 抗体
ptp2c 抗体
ptpn11 抗体
ptpn11-a 抗体
ptpn11-b 抗体
SAP-2 抗体
SH-PTP2 抗体
SH-PTP3 抗体
SHP-2 抗体
shp-2 抗体
SHP2 抗体
Shp2 抗体
shp2 抗体
Syp 抗体
SYP 抗体
wu:fa14b09 抗体
wu:fi24f03 抗体
zgc:55388 抗体
zgc:63553 抗体
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