PAI1 蛋白
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- 抗原 See all PAI1 (SERPINE1) 蛋白
- PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 序列
- MVHHPPSYVA HLASDFGVRV FQQVAQASKD RNVVFSPYGV ASVLAMLQLT TGGETQQQIQ AAMGFKIDDK GMAPALRHLY KELMGPWNKD EISTTDAIFV QRDLKLVQGF MPHFFRLFRS TVKQVDFSEV ERARFIINDW VKTHTKGMIS NLLGKGAVDQ LTRLVLVNAL YFNGQWKTPF PDSSTHRRLF HKSDGSTVSV PMMAQTNKFN YTEFTTPDGH YYDILELPYH GDTLSMFIAA PYEKEVPLSA LTNILSAQLI SHWKGNMTRL PRLLVLPKFS LETEVDLRKP LENLGMTDMF RQFQADFTSL SDQEPLHVAQ ALQKVKIEVN ESGTVASSST AVIVSARMAP EEIIMDRPFL FVVRHNPTGT VLFMGQVMEP
- 产品特性
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Purified recombinant Human PAI1 protein
Expression System: E.coli
Bioactivity: Determined by its inhibitory effect against single chain tPA induced cleavage of a chromogenic substrate in Imidazole Buffer at 37 °C. Half maximal inhibition against 1.0 µg/mL of single chain tPA was obtained at a concentration of 2.0 µg/mL. - 纯度
- > 98 % pure
- 内毒素水平
- < 0.1 ng per µg (1 EU/µg).
- Top Product
- Discover our top product SERPINE1 蛋白
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Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 24-402) protein (His tag)
SERPINE1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 1-402) protein (GST tag)SERPINE1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 24-402) protein (His tag)SERPINE1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 24-402) protein (His tag)SERPINE1 宿主: Pig 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Plasminogen Activator Inhibitor 1 (SERPINE1) (AA 86-185) protein (GST tag)SERPINE1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Plasminogen Activator Inhibitor 1 (SERPINE1) protein (His tag)SERPINE1 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute in water to a concentration of 0.1-1.0 mg/mL.
- 缓冲液
- Lyophilized from 50 mM CH3COONa, pH 5.5, with 100 mM NaCl.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- 抗原
- PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))
- 别名
- PAI1 (SERPINE1 产品)
- 别名
- PAI Protein, PAI-1 Protein, PAI1 Protein, PLANH1 Protein, SERPINE1 Protein, si:ch211-138a11.1 Protein, Planh1 Protein, PAI1A Protein, Pai1 Protein, Pai1aa Protein, Planh Protein, RATPAI1A Protein, serpin family E member 1 Protein, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 L homeolog Protein, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Protein, serine (or cysteine) peptidase inhibitor, clade E, member 1 Protein, SERPINE1 Protein, serpine1.L Protein, serpine1 Protein, Serpine1 Protein
- 背景
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Plasminogen Activator Inhibitor-1 (PAI-1, Serpin E1) is a member of the serpin family of serine protease inhibitors, and is the primary inhibitor of urokinase and tissue plasminogen activator (tPA). PAI-1 is expressed predominantly in adipose, liver and vascular tissues, and is also produced by certain tumor cells. Elevated levels of PAI-1 are associated with obesity, diabetes and cardiovascular disease, and increased production of PAI-1 is induced by various obesity related factors such as TNFa, glucose, insulin, and very-low-density lipoprotein. The obesity related elevation of PAI-1 levels along with the consequential deficiency in plasminogen activators can lead directly to increased risk of thrombosis and other coronary diseases.
Alternative Names: PAI-1, PAI 1, PAI-1 protein, PAI 1 protein, PAI1, PAI-1 protein, Serpin E1 protein, Plasminogen Activator Inhibitor-1 protein - 分子量
- 42.7 kDa
- 途径
- p53 Pathway, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration
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