IGFBP4 蛋白
Quick Overview for IGFBP4 蛋白 (ABIN935568)
抗原
See all IGFBP4 蛋白蛋白类型
生物活性
宿主
资源
纯度
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序列
- DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE
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产品特性
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Purified recombinant Human IGF BP4 protein
Expression System: Hi-5 cells
Bioactivity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells. -
内毒素水平
- < 0.1 ng per µg (1 EU/µg).
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Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 22-258) protein (His-IF2DI Tag)
IGFBP4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 1-258) (Active) protein (His tag)IGFBP4 宿主: 人 宿主: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, Imm, ELISA, AcA Active
Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 1-258) protein (GST tag)IGFBP4 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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说明
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Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Supplied as a lyophilized powder.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- RT/-20 °C
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- IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))
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别名
- IGF BP4
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背景
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IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is also found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGF-BP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF1ndependent pathway.
Alternative Names: Insulin-like Growth Factor-Binding Protein 4 protein, IGF BP-4, IGF BP 4 protein, IBP-4 protein, IGF BP4, colon cancer cell growth inhibitor protein, IGF BP-4 protein, HT29-IGF-BP protein, IGF BP-4 protein, IGF BP 4 -
分子量
- 25.8 kDa
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途径
- WNT signaling, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process
抗原
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