IGF1 蛋白
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- 抗原 See all IGF1 蛋白
- IGF1 (Insulin-Like Growth Factor 1 (IGF1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 产品特性
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Purified recombinant Human IGF1 protein
Expression System: E.coli
Bioactivity: The ED50, calculated by the dose-dependant proliferation of murine BALB\\C 3T3 cells (measured by 3H-thymidine uptake) is - 纯度
- > 98 % pure
- Top Product
- Discover our top product IGF1 蛋白
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 实验流程
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Protein quantitation was carried out by two independent methods 1. UV spectroscopy at 280 nm using the absorbency value of 0.502 as the extinction coefficient for a 0.1 % (1 mg/mL) solution.
2. Analysis by RP-HPLC, using a calibrated solution of IGF1 as a Reference Standard. - 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute in distiled water to a concentration of 0.1-1.0 mg/mL.
- 缓冲液
- Supplied as a lyophilized powder.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- RT/-20 °C
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- 抗原
- IGF1 (Insulin-Like Growth Factor 1 (IGF1))
- 别名
- IGF1 (IGF1 产品)
- 背景
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The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH, MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2, MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986, Rosenfeld, 2003).
Alternative Names: IGF-IA protein, IGF1 protein, Somatomedin C protein, MGF protein, IGF-1 protein, IGF-1, IGF-I protein, Mechano growth factor protein, IGF 1, Insulin-Like Growth Factor 1 protein, IGFI protein, IGF1, IGF 1 protein - 分子量
- 7.655 kDa
- 途径
- RTK signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation
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