HBEGF 蛋白
Quick Overview for HBEGF 蛋白 (ABIN935466)
抗原
See all HBEGF 蛋白蛋白类型
宿主
资源
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产品特性
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Purified recombinant Human HB-EGF protein
Expression System: Spodoptera frugiperda -
内毒素水平
- < 1.0 EU per 1 µg of the protein by the LAL method.
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Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 24-160) protein (Fc Tag)
HBEGF 宿主: 小鼠 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 63-148) protein (His tag)HBEGF 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 20-160) protein (Fc Tag)HBEGF 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 24-160) protein (His tag)HBEGF 宿主: 小鼠 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Heparin-Binding EGF-Like Growth Factor (HBEGF) (AA 63-148) (Active) protein (His tag)HBEGF 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Supplied as a lyophilized powder.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- RT/-20 °C
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- HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))
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别名
- HB-EGF
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背景
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HBEGF was originally purified based on its heparinbinding property and mitogenic activity on BALB3T3 fibroblasts from the conditioned medium of the human U937 histiocytic lymphoma cell line. The natural protein has an apparent molecular mass of 19 23 kDa and exists in multiple forms as a result of heterogenous Oglycosylation and/or Nterminal truncation. In addition to fibroblasts, HB EGF is also a potent mitogen for keratinocytes and smooth muscle cells but not for capillary endothelial cells. HBEGF is produced in monocytes and macrophages. In addition, transcription of HBEGF can be induced in vascular endothelial cells as well as aortic smooth muscle cells (SMC), suggesting that HB EGF may have an important role in the pathogenesis of atherosclerosis.
Alternative Names: Heparin Binding Epidermal Growth Factor protein, HB EGF protein -
途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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