VEGFR2/CD309 Protein (AA 789-1356)
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Quick Overview for VEGFR2/CD309 Protein (AA 789-1356) (ABIN7939743)
抗原
See all VEGFR2/CD309 (VEGFR2) 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 789-1356
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原理
- Recombinant KDR / VEGFR2 (789-1356) protein
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VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (Biotin,His-Avi Tag)
VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (His-Avi Tag)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE, > 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (mFc Tag,Biotin)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (His tag)VEGFR2 宿主: 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (mFc Tag)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (His tag)HPLC verified VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (His tag)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
VEGF Receptor 2 (VEGFR2) (AA 20-762) (Active) protein (His tag)VEGFR2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
VEGF Receptor 2 (VEGFR2) (AA 20-762) (Active) protein (Fc Tag)VEGFR2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (His tag,AVI tag,Biotin)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant KDR / VEGFR2 (789-1356) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
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别名
- KDR & VEGFR2
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背景
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Protein Background: KDR (Kinase Insert Domain Receptor) is a tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD and plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. KDR promotes proliferation, survival, migration and differentiation of endothelial cells and promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Diseases associated with KDR is infantile capillary hemangiomas.
Short Description: Recombinant KDR / VEGFR2 (789-1356) protein that includes amino acids 789-1356 of human KDR protein (accession number NP_002244.1) with a N-terminal FLAG tag. The molecular weight of the protein is 64.4 kDa.
Aliases: VEGFR2, Flk-1
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途径
- RTK signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
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