VEGFR2/CD309 Protein (AA 807-1356) (His-GST)
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Quick Overview for VEGFR2/CD309 Protein (AA 807-1356) (His-GST) (ABIN7317118)
抗原
See all VEGFR2/CD309 (VEGFR2) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 807-1356
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标记
- This VEGFR2/CD309 protein is labelled with His-GST.
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原理
- Recombinant Human VEGFR2/Flk-1/KDR Protein (His &GST Tag)
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序列
- Asp807-Val1356
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产品特性
- A DNA sequence encoding the human KDR (NP_002244) (Asp807-Val1356) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 10 nmol/min/mg using Poly(Glu, Tyr) 4:1 as substrate.
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VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (Biotin,His-Avi Tag)
VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (His-Avi Tag)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE, > 95 % as determined by HPLC
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (mFc Tag,Biotin)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (His tag)VEGFR2 宿主: 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (mFc Tag)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (His tag)HPLC verified VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) protein (His tag)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, AM, ADA, IA
VEGF Receptor 2 (VEGFR2) (AA 20-762) (Active) protein (His tag)VEGFR2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
VEGF Receptor 2 (VEGFR2) (AA 20-762) (Active) protein (Fc Tag)VEGFR2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
VEGF Receptor 2 (VEGFR2) (AA 20-764) (Active) protein (His tag,AVI tag,Biotin)VEGFR2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 50 mM Tris, 100 mM NaCl, pH 8.0, 10 % glycerol, 2 mM GSH
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
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别名
- VEGFR2/Flk-1/KDR
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背景
- CD309,FLK-1,FLK1,Fetal liver kinase 1,Flk-1,KDR,Kinase insert domain receptor,Protein-tyrosine kinase receptor flk-1,VEGFR,VEGFR-2,VEGFR2,Vascular endothelial growth factor receptor 2,VEGFR2, also called as KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the inhibition of VEGFR2 activity and its downstream signaling are important targets for the treatment of diseases involving angiogenesis. VEGFR2 transduces the major signals for angiogenesis via its strong tyrosine kinase activity. However, unlike other representative tyrosine kinase receptors, VEGFR2 does not use the Ras pathway as a major downstream signaling but rather uses the phospholipase C-protein kinase C pathway to signal mitogen-activated protein (MAP)-kinase activation and DNA synthesis. VEGFR2 is a direct and major signal transducer for pathological angiogenesis, including cancer and diabetic retinopathy, in cooperation with many other signaling partners, thus, VEGFR2 and its downstream signaling appear to be critical targets for the suppression of these diseases. VEGF and VEGFR2-mediated survival signaling is critical to endothelial cell survival, maintenance of the vasculature and alveolar structure and regeneration of lung tissue. Reduced VEGF and VEGFR2 expression in emphysematous lungs has been linked to increased endothelial cell death and vascular regression.
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分子量
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Calculated MW: 89.3 kDa
Observed MW: 110 kDa
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基因ID
- 3791
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NCBI登录号
- NP_002244
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UniProt
- P35968
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途径
- RTK signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
抗原
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